Naunyn-Schmiedebergs Archiv für Pharmakologie

, Volume 267, Issue 2, pp 181–184 | Cite as

Inhibition by parasympathetic nerve stimulation of the release of the adrenergic transmitter

  • K. Löffelholz
  • E. Muscholl
Short Communications

Summary

Isolated rabbit atria were perfused with Tyrode solution containing (+)-amphetamine. Electrical stimulation of the right postganglionic sympathetic fibres caused an output of noradrenaline which was significantly decreased by simultaneous stimulation of the vagus nerves.

Key-words

Perfused Rabbit Atria Sympathetic Nerve Stimulation Release of Noradrenaline Parasympathetic Nerve Stimulation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ehinger, B., Falck, B.: Concomitant adrenergic and parasympathetic fibres in the rat iris. Acta physiol. scand.67, 201–207 (1966).Google Scholar
  2. Graham, J. D. P., Lever, L. D., Spriggs, T. L. B.: An examination of adrenergic axons around pancreatic arterioles of the cat for the presence of acetylcholinesterase by high resolution autoradiographic and histochemical methods. Brit. J. Pharmacol.33, 15–20 (1968).Google Scholar
  3. Hillarp, N.-A.: The construction and functional organization of the autonomie innervation apparatus. Acta physiol. scand.46, Suppl.157, 1–68 (1959).Google Scholar
  4. Hukovic, S., Muscholl, E.: Die Noradrenalin-Abgabe aus dem isolierten Kaninchenherzen bei sympathischer Nervenreizung und ihre pharmakologische Beeinflussung. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.244, 81–96 (1962).Google Scholar
  5. Lindmar, R., Löffelholz, K., Muscholl, E.: A muscarinic mechanism inhibiting the release of nordrenaline from peripheral adrenergic nerve fibres by nicotinic agents. Brit. J. Pharmacol.32, 280–294 (1968).Google Scholar
  6. Löffelholz, K., Muscholl, E.: A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation. Naunyn-Schmiedebergs Arch. Pharmak.265, 1–15 (1969).Google Scholar
  7. — —: Der Einfluß von d-Amphetamin auf die Noradrenalinabgabe aus dem isolierten Kaninchenherzen. Naunyn-Schmiedebergs Arch. Pharmak.266, 393–394 (1970).Google Scholar
  8. McEwen, L. M.: The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain. J. Physiol. (Lond.)131, 678–689 (1956).Google Scholar
  9. Muscholl, E.: Cholinomimetic drugs and release of the adrenergic transmitter. Symposium on: New aspects of storage and release mechanisms of catecholamines. (In press) (1970).Google Scholar
  10. Norberg, K.-A., Hamberger, B.: The sympathetic adrenergic neuron. Acta physiol. scand.63, Suppl. 238, 1–42 (1964).Google Scholar
  11. Thoenen, H., Huerlimann, A., Haefely, W.: Untersuchungen zur Frage eines cholinergischen Gliedes in der postganglionären sympathischen Transmission. Helv. physiol. pharmacol. Acta24, 229–246 (1966).Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • K. Löffelholz
    • 1
  • E. Muscholl
    • 1
  1. 1.Pharmakologisches Institut der Universität MainzDeutschland

Personalised recommendations