References
Brunnemann, A., Coper, H., Herken, H.: Biosynthese von 3-Acetylpyridin-adenindinuoleotidphosphat (3-APADP) aus Nicotinamid-adenin-dinucleotidphosphat (NADP). Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.245, 541 (1963).
Dietrich, L. S., Friedland, I. M., Kaplan, L. A.: Pyridine nucleotide metabolism: Mechanism of action of the niacin antagonist 6-amino-nicotinamide. J. biol. Chem.233, 964 (1958).
Herken, H., Lange, K.: Blocking of pentose phosphate pathway in the brain of rats by 6-aminonicotinamide. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.263, 496 (1969).
— —, Kolbe, H.: Brain disorders induced by pharmacological blockade of the pentose phosphate pathway. Biochem. biophys. Res. Commun.36, 93 (1969).
—, Neuhoff, V.: Spektrofluorometrische Bestimmung des Einbaus von 6-Aminonicotinsäureamid in die oxydierten Pyridinnucleotide der Niere. NaunynSchmiedebergs Arch. exp. Path. Pharmak.247, 187 (1964).
—, Senft, G., Zemisch, B.: Die Einschränkung des tubulären Natrium-und Kaliumtransportes durch Biosynthese 6-Aminonicotinsäureamid enthaltender Nucleotide. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.249, 54 (1964).
Johnson, W. J., McColl, J. D.: 6-Aminonicotinamide a potent nicotinamide antagonist. Science122, 834 (1955).
— —: Antimetabolic activity of 6-Aminonicotinamide. Fed. Proc.15, 284 (1965).
Noltmann, E., Bruns, F. H.: Reindarstellung und Eigenschaften von Phosphoglucose-isomerase aus Hefe. Biochem. Z.331, 436 (1959).
Parr, C. W.: Inhibition of phosphoglucose isomerase. Nature (Lond.)178, 1401 (1956).
- Parr, C. W.: Competitive inhibitors of phosphoglucose isomerase. Biochem. J.65, 34 P (1957).
Salas, M., Vinuela, E., Sols, A.: Spontaneous and enzymatically catalyzed anomerization of glucose 6-phosphate and anomeric specificity of related enzymes. J. biol. Chem.240, 561 (1965).
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Lange, K., Proft, E.R. Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. Naunyn-Schmiedebergs Arch. Pharmak. 267, 177–180 (1970). https://doi.org/10.1007/BF00999399
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DOI: https://doi.org/10.1007/BF00999399
Key-words
- 6-Aminonicotinamide
- 6-Phosphogluconate
- 6-Phospho dgluconate: NADP oxidoreductase (decarboxylating) (EC 1.1.1.44)
- K M NADP
- Ki 6-ANADP