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Die Wirkung von Histamin, Carbachol, Pentagastrin und Hühnergastrinextrakten auf die Magensekretion von nicht narkotisierten Hühnern mit einer Magenfistel

The effect of histamine, carbachol, pentagastrin and gastrin extracts from chickens on gastric secretion in unanaesthetized chickens with a gastric fistula

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Summary

  1. 1.

    The effect of histamine, carbachol, pentagastrin and gastrin extracts of different organs (glandular stomach, gizzard, duodenum) on gastric acid secretion was investigated in unanaesthetized chickens with a gastric fistula.

  2. 2.

    On a molar basis, pentagastrin was three times as potent as carbachol and 12 times as potent as histamine. The dose of pentagastrin required for stimulation of gastric secretion in chickens was very much higher than in mammals.

  3. 3.

    Extracts from the glandular stomach, the gizzard and the duodenum were free from acid secretion stimulating activity.

  4. 4.

    It was concluded that gastric acid secretion in chickens is controlled by a mechanism other than gastrin.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Tübingen, Deutschland

    H. -J. Ruoff & K. -Fr. Sewing

Authors
  1. H. -J. Ruoff
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  2. K. -Fr. Sewing
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Mit Unterstützung der Deutschen Forschungsgemeinschaft und der Gesellschaft der Freunde der Universität Tübingen.

Frau G. Frisch danken wir für die Hilfe bei der Durchführung der Untersuchungen.

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Ruoff, H.J., Sewing, K.F. Die Wirkung von Histamin, Carbachol, Pentagastrin und Hühnergastrinextrakten auf die Magensekretion von nicht narkotisierten Hühnern mit einer Magenfistel. Naunyn-Schmiedebergs Arch. Pharmak. 267, 170–176 (1970). https://doi.org/10.1007/BF00999398

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  • DOI: https://doi.org/10.1007/BF00999398

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