Summary
On the isolated guinea-pig papillary muscle heptaminol causes half maximal inotropic effect in a concentration of 4×10−4 M. A variation of the extracellular potassium concentration between 2.4 and 9.6 mM as well as a reduction of the extracellular sodium concentration from 140 mM to 70 mM have no influence on the action of heptaminol; this would have been characteristic for a digitalis-like action. The positive inotropic effect is suppressed by 5×10−4 M propranolol and by pretreatment of the animal with 5 mg/kg reserpine. The action of heptaminol, therefore, is clearly that of an indirectly acting sympathomimetic amine.
Tachyphylaxis can be demonstrated only with concentrations higher than the ED50 (4×10−4 M). A concentration of 5.5×10−4 M has no inotropic effect after the muscle has been treated with 10−2 M heptaminol.
The inotropic effect of norepinephrine is increased twentyfold by 5.5×10−4 M heptaminol after pretreatment with 3.5×10−2 M heptaminol.
Heptaminol does not influence the dose-response curves of dihydro-ouabain and of calcium.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Brandt, W., Reiter, M.: Die Wirkung von Tyramin auf den Herzmuskel. (In Vorbereitung) (1970).
Garret, J.: Contribution à l'étude pharmacodynamique du chlorhydrate d'amino 6, methyl 2, heptanol 2 (chlorhydrate d'heptaminol ou 2831 R.P.). 1. Action du chlorhydrate d'heptaminol sur l'appareil cardiovasculaire et sur le système nerveux central. Arch. int. Pharmacodyn.100, 17–34 (1954).
—, Osswald, W., Goncalves Moreira, M.: Mechanism of cardiovascular actions of heptanolamines. Brit. J. Pharmacol.18, 49–60 (1962).
Grobecker, H.: Über den Wirkungsmechanismus von Heptaminol. Naunyn-Schmiedebergs Arch. Pharmak.266, 339–340 (1970).
Loubatières, A.: Propriétés cardiotoniques d'un amino-alcool aliphatique: l'amino.6-methyl.2-heptanol.2 (2831 R.P.). Arch. int. Pharmacodyn.85, 333–356 (1951).
Marquardt, P., Pieper, K. H.: Untersuchungen zur Wirkung des Heptaminols (2-amino-6-methyl-heptaminol). Med. Welt49, 2576–2579 (1961).
Müller, P., Schatzmann, H. J., Weidmann, S.: Effets du chlorhydrate d'heptaminol sur la contraction, le potentiel d'action et le taux de potassium intracellulaire des fibres cardiaques. C. R. Soc. Biol. (Paris)158, 1850–1853 (1964).
Reiter, M.: Die Beziehung von Calcium und Natrium zur inotropen Glykosidwirkung. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.245, 487–499 (1963).
—: Die Wertbestimmung inotrop wirkender Arzneimittel am isolierten Papillarmuskel. Arzneimittel-Forsch. (Drug Res.)17, 1249–1253 (1967).
—, Schöber, H. G.: Die positiv inotrope Adrenalinwirkung auf den Meerschweinchen-Papillarmuskel bei Variation der äußeren Calcium- und Natriumkonzentration. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.250, 9–20 (1965).
—, Stickel, F. J., Weber, S.: The influence of the extracellular potassium concentration on the glyooside effects upon contractile force and action potential duration of the guinea-pig papillary muscle. Experientia (Basel)22, 665 (1966).
Author information
Authors and Affiliations
Additional information
Über die Ergebnisse wurde auf der Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft am 16. 3. 1970 in Mainz berichtet.
Ich danke Frl. Monika Klein für ihre kompetente Mitarbeit.
Rights and permissions
About this article
Cite this article
Reiter, M. Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel. Naunyn-Schmiedebergs Arch. Pharmak. 267, 114–122 (1970). https://doi.org/10.1007/BF00999394
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00999394