Metabolic Brain Disease

, Volume 3, Issue 3, pp 211–216 | Cite as

Inhibitory neuromodulators do not alter the course of experimental hepatic encephalopathy

  • David Rzepczynski
  • Leslie Zieve
  • Sandra Lindblad
Original Contributions


The neuromodulators, adenosine, serotonin, and glycine, did not alter the course of hepatic encephalopathy (HE) that followed a portacaval shunt and hepatic artery ligation in rats. The substances were instilled into the brain ventricle through an intraventricular cannula in doses that affect other aspects of behavior in the normal rat (adenosine, suppression of food intake; serotonin, loss of muscle strength and ataxia; glycine, leaning and circling). A subconvulsive dose of the glycine antagonist, strychnine, also had no effect on the course of HE. A large dose of the adenosine antagonist, caffeine, had a depressive rather than excitatory effect and shortened the time taken to induction of coma. These studies and a similar previous one with γ-aminobutyric acid (GABA) suggest that the inhibitory neuromodulators do not have a prominent role in the pathogenesis of hepatic coma.

Key words

adenosine caffeine glycine hepatic encephalopathy neuromodulators serotonin strychnine 


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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • David Rzepczynski
    • 1
  • Leslie Zieve
    • 1
  • Sandra Lindblad
    • 1
  1. 1.VA and Hennepin County Medical CentersUniversity of MinnesotaMinneapolis

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