Summary
Decrease of histamine in brain after decaborane prevents nystagmus caused by horizontal rotation. This occurs independently of the decrease of serotonin and noradrenaline. Inhibition of cholinacetyltransferase did not prevent nystagmus.
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References
Brand, J. J., Perry, W. L. M.: Drugs used in motion sickness. Pharmacol. Rev.18, 895 (1966).
Fuller, R. W., Hines, C. W., Mills, J.: Lowering of brain serotonin level by chloramphetamines. Biochem. Pharmacol.14, 483 (1964).
Medina, M. A., Landez, J. H., Foster, L. L.: Inhibition of tissue histamine formation by decaborane. J. Pharmacol. exp. Ther.169, 132 (1969).
Merritt, J. H., Sulkowski, T. S.: Inhibition of aromaticl-amino acid decarboxylation by decaborane. Biochem. Pharmacol.16, 369 (1967).
Onn-Leng, Ch., Webster, R. A.: Effect of tetrabenazine andα-methyl-m-tyrosine on exploratory activity and brain catecholamines in rats. Brit. J. Pharmacol.41, 691 (1971).
Schayer, R. W., Reilly, M. A.: Effect of decaborane on histamine formation in mice. J. Pharmacol. exp. Ther.177, 177 (1971).
Smith, J. C., Cavallito, C. J., Foldes, F. F.: Choline acetyltransferase inhibitors: A group of styryl-pyridine analogs. Biochem. Pharmacol.16, 2438 (1967).
Stern, P.: Beitrag zur Wirkungsweise des Histamins im Zentralnervensystem. Wien. klin. Wschr.80, 131 (1968).
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Stern, P. Influence of histamine depletion in rat brain on the rotatory nystagmus. Naunyn-Schmiedebergs Arch. Pharmak. 271, 204–205 (1971). https://doi.org/10.1007/BF00998581
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DOI: https://doi.org/10.1007/BF00998581