Neurochemical Research

, Volume 18, Issue 8, pp 869–874 | Cite as

Octopamine receptor subtypes and their modes of action

  • Peter D. Evans
  • Sandra Robb
Overview

Abstract

Octopamine receptor subclasses were first proposed to explain differences in the pharmacological profiles of a range of physiological responses to octopamine obtained in the extensor-tibiae neuromuscular preparation of the locust. Thus, OCTOPAMINE1 receptors which inhibit an endogenous myogenic rhythm, increase intracellular calcium levels. Also OCTOPAMINE2 receptors which modulate neuromuscular transmission in this preparation, increase the level of adenylate cyclase activity. The current status of this classification is reviewed by examining the pharmacology of responses to octopamine in a range of preparations. It is concluded that the distinction between OCTOPAMINE1 and OCTOPAMINE2 receptor types is still valid, but that OCTOPAMINE2 receptors exhibit some tissue specific variations. Studies on a clonedDrosophila octopamine/tyramine (phenolamine) receptor are discussed and illustrate many of the difficulties presently encountered in making a definitive classification of octopamine receptors. These include the possibilities that single receptors may activate multiple second messenger systems and that different agonists may differentially couple the same receptor to different second messenger systems.

Key Words

Octopamine receptors subtypes Drosophila 

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Peter D. Evans
    • 1
  • Sandra Robb
    • 1
  1. 1.AFRC Laboratory of Molecular Signilling, Dept. of ZoologyUniversity of CambridgeCambridgeUK

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