Skip to main content

Methods for measuring the renal uptake rate of99mTc-dimercaptosuccinic acid (DMSA) : a comparative study

European Journal of Nuclear Medicine volume 16, pages 725–731 (1990)Cite this article

Abstract

A comparative study of the renal uptake rate of99mTc-dimercaptosuccinic acid (DMSA) was performed using a phantom study and clinical data from 100 patients (200 kidneys) with a variety of renal diseases. The measurement methods for renal uptake rate studied here include a posterior-view method, a conjugate-view method, and a method using single photon emission computed tomography (SPECT). The renal uptake rates obtained by the posterior-view method significantly (P<0.001) depended on kidney depth correction. With the SPECT method, the cut-off level for delineating the kidney was changed according to the background count ratio using the results of the phantom study. The renal uptake rates obtained by the SPECT method correlated significantly (P<0.001) with those obtained by other methods, and there were no significant differences as compared with those obtained by the conjugate-view method. An analysis of error with the above methods indicated that the error relating to the sensitivity to body thickness was smallest for the SPECT method and greatest for the posterior-view method. In terms of measurement of renal uptake rate only, the conjugate-view method is considered the most useful because it needs no kidney depth correction and requires very little additional effort or examination time.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  • Axelsson B, Msaki P, Israelsson A (1984) Subtraction of Comptonscattered photons in single photon emission computerized tomography. J Nucl Med 25:490–494

    Google Scholar 

  • Bourguet P, Delaval P, Herry JY (1986) Direct quantitation of thoracic gallium-67 uptake in sarcoidosis. J Nucl Med 27:1550–1556

    Google Scholar 

  • Chang LT (1978) A method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci 25:638–643

    Google Scholar 

  • Fleming JS, Kreast CM, Waller DG, Ackay D (1987) Measurement of glomerular filtration rate with 99mTc-DTPA: a comparison of gamma camera methods. Eur J Nucl Med 13:250–253

    Google Scholar 

  • Gates GF (1982) Glomerular filtration rate: estimation from fractional renal accumulation of B99mTc-DTPA (stannous). Am J Roentgenol 138:565–570

    Google Scholar 

  • Grossman LW, Fernandez-Ulloa M, Lukes SJ, Mantil J (1985) Gallium-67 lung uptake: conjugate-view technique. Radiology 157:789–793

    Google Scholar 

  • Gruenewald SM, Collins LT, Fawdry RM (1985) Kidney depth measurement and its influence on quantitation of function from gamma camera renography. Clin Nucl Med 10:398–401

    Google Scholar 

  • Hammond ND, Moldofsky PJ, Beardsley MR, Mulhern CB Jr (1984) External imaging techniques for quantitation of distribution of I-131F(ab′) z fragments of monoclonal antibody in humans. Med Phys 11:778–783

    Google Scholar 

  • Ito T, Takeda K, Toyota S, Maeda H, Kitano T, Nakagawa T, Yamaguchi N (1984) Estimation of glomerular filtration rate from fractional renal uptake of 99mTc-DTPA. Kaku Igaku 21:1579–1586 (in Japanese)

    Google Scholar 

  • Itoh K, Arakaiva M (1987) Re-estimation of renal function with s9-Tc-DTPA by the Gate's method. Kaku Igaku 24:389–396 (in Japanese)

    Google Scholar 

  • Kan MK, Hopkins BG (1979) Measurement of liver volume by emission computed tomography. J Nucl Med 20:514–520

    Google Scholar 

  • Kawamura J, Hosokawa S, Yoshida O, Fujita T, Ishii Y, Torizuka K (1978) Validity of 99mTc dimercaptosuccinic acid renal uptake for an assessment of individual kidney function. J Urol 119:305–309

    Google Scholar 

  • Kawamura J, Itoh H, Yoshida O, Fujita T, Torizuka K (1984) In vivo estimation of renal volume using a rotating gamma camera for Tc-99m dimercaptosuccinic acid renal imaging. Eur J Nucl Med 9:168–172

    Google Scholar 

  • Keller AM, Simon TR, Smitherman TC, Malloy CR, Dehmer GJ (1987) Direct determination of the attenuation coefficient for radionuclide volume measurements. J Nucl Med 28:102–107 Murase K, Itoh H, Mogami H, Ishine M, Kawamura M, lio A.

    Google Scholar 

  • Hamamoto K (1987) A comparative study of attenuation correction algorithms in single photon emission computed tomography. Eur J Nucl Med 13:55–62

    Google Scholar 

  • Murase K, Tanada S, Yasuhara Y, Mogami H, Iio A, Hamamoto K (1989a) SPECT volume measurement using an automatic threshold selection method combined with a V filter. Eur J Nucl Med 15:21–25

    Google Scholar 

  • Murase K, Tanada S, Higashino H, Yamada M, Miyagawa M, Iio A, Hamamoto K (1989b) A unified computer program for assessment of attenuation correction and data acquisition methods in single photon emission computed tomography (SPECT). Eur J Nucl Med 15:248–253

    Google Scholar 

  • Nimmo MJ, Merrick MV, Allan PL (1987) Measurement of relative renal function. A comparison of methods and assessment of reproducibility. Br J Radiol 60:861–864

    Google Scholar 

  • Shepp LA, Logan BE (1974) Reconstruction interior head tissue from X-ray transmissions. IEEE Trans Nucl Sci 21:228–236

    Google Scholar 

  • Taki J, Bunko H, Tada A, Nakajima K, Nanbu I, Skiire Y, Tonami N, Hisada K (1985) Basic evaluation of right and left ventricular volume using single-photon emission computed tomography. Kaku Igaku 22:1539–1544 (in Japanese)

    Google Scholar 

  • Tauxe WN, Burke FC (1968) Kidney depth and isotope renography. J Nucl Med 9:225–226

    Google Scholar 

  • Tauxe WN, Soussaline F, Todd-Pokropek A, Cao A, Collard P, Richard S, Raynaud C, Itti R (1982) Determination of organ volume by single-photon emission tomography. J Nucl Med 23:984–987

    Google Scholar 

  • Tonnesen KH, Munck O, Hald T (1975) Influence on the radiorenogram of variation in skin to kidney distance and the clinical importance hereoff. In: Blaufox MD, Funck-Bretano JL (eds) Radionuclides in nephrology. Grime & Stratton, New York, pp 79–86

    Google Scholar 

  • Wujanto R, Lawson RS, Prescott MC, Testa HJ (1987) The importance of using anterior and posterior views in the calculation of different renal function using 99mTc-DMSA. Br J Radiol 60:869–872

    Google Scholar 

Download references

Author information

Affiliations

  1. Department of Radiology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan

    Kenya Murase, Shuji Tanada, Masahiro Ishine & Ken Hamamoto

  2. Department of Urology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan

    Masayoshi Yokoyarna

Authors
  1. Kenya Murase
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shuji Tanada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masahiro Ishine
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masayoshi Yokoyarna
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ken Hamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Murase, K., Tanada, S., Masahiro, I. et al. Methods for measuring the renal uptake rate of99mTc-dimercaptosuccinic acid (DMSA) : a comparative study. Eur J Nucl Med 16, 725–731 (1990). https://doi.org/10.1007/BF00998179

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00998179

Key words

  • Posterior-view method
  • Conjugate-view method
  • SPECT
  • 99mTc-dimercaptosuccinic acid (DMSA)
  • Renal uptake rate