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European Journal of Nuclear Medicine

, Volume 16, Issue 8–10, pp 705–711 | Cite as

Segmental analysis of SPECT99mTc-methoxy isobutyl isonitrile and201Tl myocardial imaging in ischaemic heart disease

  • I. M. Hassan
  • M. M. J. Mohammed
  • C. Constantinides
  • S. Sadek
  • M. Nair
  • N. Belani
  • A. M. Yousef
  • H. M. Abdel-Dayem
Original Article

Abstract

To study the potential usefulness of99mTc-methoxy isobutyl isonitrile (99mTc-MIBI) as a substitute for201Tl in assessing patients with ischaemic heart disease, 24 patients underwent 1 day rest and exercise99mTc-MIBI single photon emission computerised topography (SPECT) 1 week after SPECT exercise201Tl. All patients were catheterized within 1 month after myocardial imaging. In 17 patients, resting first pass radionuclide angiography (FPRNA) was performed with99mTc-MIBI. The heart to lung ratio for99mTc-MIBI and201Tl was calculated both at rest and exercise. The segmental analysis for myocardial perfusion reveals that 87/96 segments (91 %) were correctly classified by SPECT201Tl and 84/96 segments (88%) were correctly classified by99mTc-MIBI. A significant correlation was present between LVEF measured by99mTc-MIBI FPRNA and contrast ventriculography (r = 0.85,P < 0.0001). The heart to lung ratio both at rest and exercise for99mTc-MIBI is significantly higher than201Tl (P < 0.01 and <0.001 respectively). We conclude that99mTc-MIBI is a promising agent for simultaneous evaluation of myocardial perfusion and cardiac function.

Key words

99mTc-MIBI Myocardial imaging Ischaemic heart diseases 

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References

  1. Abdel-Dayem HM, Kouris K, Hassan IM, Taha B, Constantinides C, Nair M, Belani N (1988) Calculation of ejection fraction (EF) from dual gated SPECT myocardial imaging with Tc-99m methoxy isobutyl isonitrile (MIBI). Eur J Nucl Med 14:367 (abstr.)Google Scholar
  2. Baillet GY, Mena IG, Kuperus JH, Robertson JM, French WJ (1989) Simultaneous technetium-99m MIBI angiography and myocardial perfusion imaging. J Nucl Med 30:38–44Google Scholar
  3. DePasquale EE, Nody AC, DePuey EG, Garcia EV, Pilcher G, Bredlau C, Roubin G, Gaber A, Gruentizig A, D'Amato P, Berger HJ (1988) Quantitative thallium-201 tomography for identification and localization coronary artery disease. Circulation 77:316–327Google Scholar
  4. DePuey EG, Guertler-Krawczynska E, Robbins WL (1988) Thallium-201 SPECT in coronary artery disease patients with left bundle branch block. J Nucl Med 29:1479–1485Google Scholar
  5. Faber TL, Khan JK, Akers MS, Corbett JR (1988) Automatic calculation of LV volumes and EF from gated RP-30 tomograms. J Nucl Med 29:805 (abstr.)Google Scholar
  6. Hassan IM, Mohammed MMJ, Constantinides C, Sadek S, Nair M, Belani N, Yousef AM, Abdel-Dayem (1988) Segmental analysis of SPECT Tc-99m methoxy isonutyl isonitrile (RP-30) and thallium-201 myocardial imaging in ischaemic heart disease (IHD). Eur J Nucl Med 14:250 (abstr.)Google Scholar
  7. Hassan IM, Mohammed MMJ, Constantinides C, Nair M, Belani N, Abdel-Dayem HM (1989) Problems of duodenogastric reflux in Tc-99m RP-30: planar, tomographic and Bull'seye display. Clin Nucl Med 4:286–289Google Scholar
  8. Herman GT (1979) Image reconstruction from projections: implementation and applications, Springer, Berlin Heidelberg New YorkGoogle Scholar
  9. Holman BL (1984) Nuclear cardiology. In: Braunwald E (ed) Heart disease. 2nd Ed. Philadelphia: Saunders, pp 351–399Google Scholar
  10. Holman BL, Sporn V, Jones AG, Bengamin Sia SJ, Perez Balino N, Davison A, Janes JL, Kronavge JF, Mitta AEA, Camin LL, Campbellos, Williams SJ, Carpenter AT (1987) Myocardial imaging with technetium-99m CPI: Initial experience in the human. J Nucl Med 28:13–18Google Scholar
  11. Maddahi J, Roy L, Van Train K, Brown D, Merz R, Waxman A, Berman D (1986a) The first United States experience in normal human myocardial imaging with Tc-99m methoxy isobutyl isonitrile RP-30. Clin Nucl Med 11:P17 (abstr.)Google Scholar
  12. Maddahi J, Van Train KF, Wang C, Gurewitz J, Prigent F, Youngkin C, Friedman J, Berman D (1986b) Comparison of thallium201 SPECT and planar imaging for evaluation of coronary artery disease. J Nucl Med 27:999 (abstr.)Google Scholar
  13. McKusick K, Holman BL, Jones AG, Davison A, Bosto MA, Rigo P, Sporn V, Vosberg H, Morehi J (1986a) Comparison of three Tc-99m isonitriles for detection of ischaemic heart disease in humans. J Nucl Med 27:878 (abstr.)Google Scholar
  14. McKusick KA, Holman BL, Rigo P, Sporn V, Jones AG, Davison A, DuPras G, Taillefer R, Billerica N (1986b) Human myocardial imaging with Tc-99m isonitriles. Circulation 74:11–296 (abstr.)Google Scholar
  15. Okada RD, Glover D, Gaffney T, Williams S (1988) Myocardial kinetics of technetium-99m hexakis-2-methoxy-2-methylpropylisonitrile. Circulation 77:491–498Google Scholar
  16. Ritchie J, Williamd DL, Harp G, Stratton JL, Caldwell HI (1982) Transaxial tomography with thallium-201 for detecting remote myocardial infarction. Comparison with planar imaging. Am J Cardiol 50:1236–1241Google Scholar
  17. Rothendler JA, Okada RD, Wilson RA, Brown KA, Boucher CA, Strauss HW, Post GM (1985) Effect of a delay in commencing imaging on the ability to detect transient thallium defects. J Nucl Med 26:880–883Google Scholar
  18. Tamaki S, Nakajima H, Murakam T, Yuiy, Kambara H, Kadota K, Youshida A, Kawai C, Tamaki N, Mukai T, Ishii Y, Torizuka K (1982) Estimation of infarct size by myocardial emission computed tomography with thallium-201 and its relation to creative kinase-MB release after myocardial infarctions in man. Circulation 66:994–1001Google Scholar
  19. Williams SJ, Mousa SA, Morgan RH, Carroll TR, Mahev LJ (1986) Pharmacology of Tc-99m isonitriles: Agent with favourable characteristics for heart imaging. J Nucl Med 27:877 (abstr.)Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • I. M. Hassan
    • 1
  • M. M. J. Mohammed
    • 2
  • C. Constantinides
    • 1
  • S. Sadek
    • 1
  • M. Nair
    • 1
  • N. Belani
    • 1
  • A. M. Yousef
    • 2
  • H. M. Abdel-Dayem
    • 1
  1. 1.Department of Nuclear MedicineKuwait University and Ministry of Public HealthKuwait
  2. 2.Department of CardiologyKuwait University and Ministry of Public HealthKuwait

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