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Beeinflussung der Capillarpermeabilität in der Meerschweinchenhaut durch Anaphylatoxin (AT)

Increase in vascular permeability of guinea-pig skin induced by anaphylatoxin

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Summary

The effect of anaphylatoxin (AT) on vascular permeability has been investigated by injecting Evans-blue intravenously into guinea pigs and recording the blue spots developed at sites of intracutaneously injected AT; for quantitation the area of the spots or the amount of extracted dye was measured.

The permeability increasing effect in guinea-pig skin of AT is nearly as strong as that of kallidin (w/w) and about 100 times stronger than that of histamine.

Antihistamine drugs reduce the incrase in vascular permeability induced by AT, but do not block it completely. It is concluded, that the effect of AT is partly mediated by liberated histamine and partly due to a direct action.

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Authors and Affiliations

  1. Abteilung Biochemische Pharmakologie, Max-Planck-Institut für experimentelle Medizin, Göttingen

    G. Bodammer & W. Vogt

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  1. G. Bodammer
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  2. W. Vogt
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Der Firma Sandoz danken wir für die Überlassung von Kallidin.

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Bodammer, G., Vogt, W. Beeinflussung der Capillarpermeabilität in der Meerschweinchenhaut durch Anaphylatoxin (AT). Naunyn-Schmiedebergs Arch. Pharmak. 266, 255–260 (1970). https://doi.org/10.1007/BF00997286

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  • DOI: https://doi.org/10.1007/BF00997286

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