Naunyn-Schmiedebergs Archiv für Pharmakologie

, Volume 268, Issue 1, pp 114–118 | Cite as

Action of caerulein and related substances on the sphincter of Oddi

  • A. Agosti
  • P. Mantovani
  • L. Mori


The effects of caerulein and some related substances were investigated on the sphincter of Oddi which had been contracted by morphine in the guinea-pig, and on the isolated terminal bile duct in the calf. In the first test caerulein (50–100 ng/kg i.v.) was the most potent spasmolytic drug whereas in the second test the peptide (0.75-1 Μg/ml) produced actually a spasmogenic effect. The peptide resembled epinephrine in both preparations.


Morphine Caerulein Sphincter of Oddi 


Morphin Caerulein Sphincter Oddi 


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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • A. Agosti
    • 1
  • P. Mantovani
    • 1
  • L. Mori
    • 1
  1. 1.Institute of PharmacologyUniversity of ParmaParmaItaly

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