Action of caerulein and related substances on the sphincter of Oddi
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The effects of caerulein and some related substances were investigated on the sphincter of Oddi which had been contracted by morphine in the guinea-pig, and on the isolated terminal bile duct in the calf. In the first test caerulein (50–100 ng/kg i.v.) was the most potent spasmolytic drug whereas in the second test the peptide (0.75-1 Μg/ml) produced actually a spasmogenic effect. The peptide resembled epinephrine in both preparations.
Key-WordsMorphine Caerulein Sphincter of Oddi
SchlüsselwörterMorphin Caerulein Sphincter Oddi
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- Benzi, G., Crema, A.: Metodo di studio dello sfintere isolato di Oddi. Boll. Soc. ital. Biol. sper.36, 664–667 (1960).Google Scholar
- Bertaccini, G., Agosti, A.: Action of caerulein on intestinal motility in man. Gastroenterology (in press).Google Scholar
- —, Ballarini, G., Agosti, A., Zannetti, G.: Action of caerulein on the biliary system of the dog. Arch. int. Pharmacodyn.183, 261–269 (1970).Google Scholar
- —, Braibanti, T., Uva, F.: Cholecystokinetic activity of the new peptide caerulein in man. Gastroenterology56, 862–867 (1969).Google Scholar
- Bertaccini, G., De Caro, G., Endean, R., Erspamer, V., Impicciatore, M.: The actions of caerulein on the smooth muscle of the gastrointestinal tract and the gall bladder. Brit. J. Pharmacol.34, 291–310 (1968).Google Scholar
- Crema, A., Benzi, G., Frigo, G. M., Berté, F.: Method for evaluating spasmolytic activity of drugs on the bile duct. J. Pharm. Pharmacol.17, 405–408 (1965).Google Scholar
- Del Tacca, M., Soldani, G., Crema, A.: Experiments on the mechanism of action of caerulein at the level of the guinea pig ileum and colon. Agents and Actions (in press).Google Scholar
- Lin, T. M.: Discussion to the paper of Erspamer V. Nobel Symposium XVI-Frontiers in Gastrointestinal Hormone Research. July, 20-21, 1970. Wenner Gren Center, Stockholm.Google Scholar
- —, Spray, G. F.: Effect of pentagastrin, cholecystokinin, caerulein and glucagon on the choledochal resistance and bile flow of conscious dog. Gastroenterology56, 1178 (1969).Google Scholar
- Mantovani, P.: An inhibitory action of caerulein on the isolated guinea-pig ileum. Experientia (Basel) (in press).Google Scholar