Summary
Sodium turn-over during renal hypertension was studied in rats with unilateral renal-artery constriction (Gbl. rats), unilaterally nephrectomized rats with the contralateral renal artery clamped (Gbl.-nephrex rats) and corresponding controls (intact or nephrectomized rats). The animals received a diet containing a 0.6%-NaCl- and subsequently a low sodium diet, containing 0.01% NaCl.
In the first series of experiments,22Na was injected intravenously, and after it had mixed with exchangeable sodium, its rate of elimination was determined from the decline in total body radioactivity. While receiving a sodium-containing diet, Gbl. rats eliminated22Na more rapidly than the controls, i.e. they displayed a slightly elevated sodium turn-over, whereas no difference was evident between Gbl.-nephrex and nephrex rats. During the first seven days after changing to a low-sodium diet, Gbl. rats lost twice as much22Na as the other groups, which all showed a similar rate of22Na loss. In the second series of studies, the renal elimination of sodium was measured each day for 8 h. During the first few days on a low-sodium diet, sodium was eliminated more rapidly by Gbl. rats than by the other groups. In comparison with Gbl.-nephrex, intact or nephrex rats, Gbl. rats thus exhibited a diminished capacity ro retain sodium. At the end of eight days on a low-sodium diet, the serum sodium concentrations were the same in all groups, and exchangeable sodium was increased only in Gbl.-nephrex rats. The hypothesis is advanced that the continuous activation of the renin-angiotensin-aldosterone system in Gbl. rats is the result of a counter-regulatory mechanism brought into play to restore the sodium balance.
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Herrn P. Kaiser und Herrn D. Baltisberger sei an dieser Stelle für sorgfältige Mitarbeit gedankt.
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Brunner, H. Gesteigerter Na-Umsatz bei renal hypertonischen Ratten. Naunyn-Schmiedebergs Arch. Pharmak. 267, 278–292 (1970). https://doi.org/10.1007/BF00997098
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DOI: https://doi.org/10.1007/BF00997098