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Unexpected temperature dependence of potassium release from the isolated perfused rat liver

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Summary

At temperatures from 15–25° C perfused rat livers take up potassium from the perfusion medium or release small amounts of the cation. Both increasing or decreasing temperature enhance the K+-release in the absence as well as in the presence of red cells. Two possible explanations of this phenomenon, hypoxia and phase-transition of the plasma membrane, are discussed.

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References

  • Frimmer, M., Kramer, R.: Kationenbewegungen in der isoliert perfundierten Rat-tenleber. Z. ges. exp. Med.152, 269 (1970).

    Google Scholar 

  • —, Kreh, W.: The role of oxidative and glycolytic metabolism in cation transport of the isolated rat liver perfused with, an erythrocyte-free medium. Naunyn-Schmiedebergs Arch. Pharmak.268, 119 (1971).

    Google Scholar 

  • Kessler, M., Schubotz, R.: Die O2-Versorgung der hämoglobinfrei perfundierten Rattenleber. In Stoffwechsel der isoliert perfundierten Leber. 3. Konferenz der Ges. Biol. Chem. in Oestrich, S. 12–24. Berlin-Heidelberg-New York: Springer 1968.

    Google Scholar 

  • Overath, P., Schairer, H. U., Stoffel, W.: Correlation of in vivo and in vitro phase transitions of membrane lipids in Escherichia coli. Proc. nat. Acad. Sci. (Wash.)67, 606 (1970).

    Google Scholar 

  • Schairer, H. U., Overath, P.: Lipids containing trans-unsaturated fatty acids change the temperature characteristic of thiomethylgalactoside accumulation in Escherichia coli. J. molec. Biol.44, 209 (1969).

    Google Scholar 

  • Schimassek, H.: Metabolite des Kohlenhydratstoffwechsels der isoliert perfundierten Rattenleber. Biochem. Z.336, 460 (1963).

    Google Scholar 

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This work is supported by the Deutsche Forschungsgemeinschaft.

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Frimmer, M., Kreh, W. Unexpected temperature dependence of potassium release from the isolated perfused rat liver. Naunyn-Schmiedebergs Arch. Pharmak. 270, 313–315 (1971). https://doi.org/10.1007/BF00997030

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  • DOI: https://doi.org/10.1007/BF00997030

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