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Effect of cerebral ischemia on synaptosomal uptake and release of3H-5-hydroxytryptamine in adult and young mongolian gerbils

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Abstract

Cerebal ischemia induced by bilateral common carotid artery occlusion (15min) with and without release (1 hr) served as a model for comparative regional studies of synaptosomal 3H-5-hydroxytryptamine (3H-5-HT) uptake and release in adult and young gerbils. A decreased uptake and an increased release of 5-HT was observed in the adult after ischemia alone and/or ischemia with reflow. At the same time, 5-HT uptake was not affected except in the cortex and the release was reduced in the young. These findings indicate that the same ischemic insults affect differently the synaptosomal uptake and/or release of 5-HT in adult and young brain.

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Authors and Affiliations

  1. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 20892, Bethesda, Maryland

    Vesna Cvejic, Kazuo Kumami & Maria Spatz

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  1. Vesna Cvejic
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  2. Kazuo Kumami
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  3. Maria Spatz
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Cvejic, V., Kumami, K. & Spatz, M. Effect of cerebral ischemia on synaptosomal uptake and release of3H-5-hydroxytryptamine in adult and young mongolian gerbils. Metab Brain Dis 5, 1–6 (1990). https://doi.org/10.1007/BF00996973

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  • DOI: https://doi.org/10.1007/BF00996973

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