Zusammenfassung
Die Glykoproteine in Erythrocytenmembranen von Individuen, die die seltenen Allele am MNSs BlutgruppenlokusMiltenberger (Mi-) III, V, M v undM k aufweisen, wurden mit Natrium-Dodecylsulfat Polyacrylamidgel elektrophoretischen Techniken untersucht. Die Ergebnisse erbringen Evidenz dafür, da\ die GeneMi-III und -V zur Synthese von Ss Sialoglykoproteinen mit verÄnderten elektrophoretischen MobilitÄten führen. Die Mi-V VerÄnderung ist zusÄtzlich durch einen verminderten MN Glykoproteingehalt charakterisiert. Das AllelM v führt zu einem verminderten Ss Glykoproteingehalt. Ergebnisse an gewöhnlichenM k undM k/Mi -III Zellen erbringen Evidenz dafür, da\ das AllelM k kein Ss Glykoprotein produziert.
Summary
The glycoproteins in erythrocyte membrane from individuals exhibiting the rare alleles at the MNSs blood group locusMiltenberger (Mi-) III, V, M v andM k were studied by sodium-dodecylsulfate polyacrylamide gel electrophoretic techniques. The results suggest that the genesMi- III and -V give rise to the formation of Ss sialoglycoproteins whose electrophoretic mobilities are altered. TheMi-V alteration is additionally associated with a decreased MN glycoprotein content. The alleleM v leads to a decreased Ss glycoprotein content. Data on ordinaryM k andM k/Mi-III red cells suggest that the gene complexM k does not give rise to the synthesis of Ss glycoprotein.
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Dedicated to Professor Dr. R. Gross on the occasion of his 60th birthday. Part of the work described in the present paper was presented at the 7th International Congress of the Society for Forensic Haematogenetics, Hamburg, September 25-29, 1977
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Dahr, W., Longster, G., Uhlenbruck, G. et al. Studies on Miltenberger class III, V, Mv and Mk red cells. Blut 37, 129–138 (1978). https://doi.org/10.1007/BF00996762
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DOI: https://doi.org/10.1007/BF00996762