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Ferritin in bone marrow and serum in iron deficiency and iron overload

Ferritin in Knochenmark und Serum bei Eisenmangel und Eisenüberladung

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Zusammenfassung

Das Serumferritin gilt als Parameter des Speichereisens. Wir haben deshalb das NichthÄmoglobineisen und das Ferritin im Knochenmark sowie das Serumferritin untersucht. Die Bestimmungen wurden bei Patienten mit EisenmangelanÄmie und mit Eisenüberladung durchgeführt. Als Kontrolle dienten Patienten ohne Störung des Eisenhaushaltes.

Es ergab sich eine strenge Korrelation zwischen dem NichthÄmoglobineisen und dem Ferritin im Knochenmark bei den Patienten mit und ohne Störung des Eisenhaushaltes. Ebenso fand sich eine Korrelation zwischen dem Ferritin im Knochenmark und dem Serumferritin. NichthÄmoglobineisen und Ferritin im Knochenmark sowie das Serumferritin sind erniedrigt bei Patienten mit EisenmangelanÄmie. Dieselben Parameter sind erhöht bei Patienten mit Eisenüberladung.

Summary

Nonheme iron and ferritin in the bone marrow and serum ferritin was investigated in patients with iron deficiency anaemia or iron overload. As controls served patients without any disturbance of the iron metabolism.

There is a precise correlation between the nonheme iron and ferritin in the bone marrow of patients with and without disturbance of iron metabolism. A correlation was also found between the ferritin in the bone marrow and the serum. Nonheme iron and ferritin in the bone marrow and serum ferritin was decreased in patients with iron deficiency anaemia. Conversely, the same parameters were increased in patients with iron overload.

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Authors and Affiliations

  1. Abteilung HÄmatologie und Onkologie, Klinikum Westend, Freie UniversitÄt Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    J. Oertel, B. M. Bombik, M. Stephan & H. Gerhartz

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  1. J. Oertel
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  2. B. M. Bombik
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  3. M. Stephan
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  4. H. Gerhartz
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Oertel, J., Bombik, B.M., Stephan, M. et al. Ferritin in bone marrow and serum in iron deficiency and iron overload. Blut 37, 113–117 (1978). https://doi.org/10.1007/BF00996760

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  • DOI: https://doi.org/10.1007/BF00996760

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