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An improved modification of cycle filtration leucopheresis

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Summary

We report about an own modification of repetitive cycle filtration leucopheresis (RFL). Compared to the method described by De Fliedner et al. (1974) it is simpler to perform, permits the use of commercially available filtration sets and thus reduces the costs of the procedure considerably. The mean yields of the granulocytes collected in 51 RFL from unconditionated normal donors amounted from 1.7 to 2.3×1010 dependent on the number of the filtration cycles performed.

Zusammenfassung

Es wird über eine Modifikation der repetitiven zyklischen Filterleukopherese (RFL) berichtet. Im Vergleich zu der von De Fliedner und Mitarbeiter (1974) beschriebenen Methode ist sie technisch einfacher durchzuführen, erlaubt die Verwendung eines kommerziell erhältlichen Filtrationsbestecks und ist dadurch beträchtlich billiger. Die mittleren Granulozytenausbeuten bei 51 RFL von unkonditionierten Normalspendern betrugen abhängig von der Anzahl der Filtrationsphasen 1,7 bis 2,3×1010.

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References

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Kretschmer, V., Mueller-Eckhardt, C. An improved modification of cycle filtration leucopheresis. Blut 35, 415–418 (1977). https://doi.org/10.1007/BF00996628

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  • DOI: https://doi.org/10.1007/BF00996628

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