Summary
The ADP- and collagen-induced aggregation of platelets in PRP of healthy probands was tested in vitro in the presence of 4 heparin preparations (Novo, Vitrum, Liquemin, Haemoderivate) and of a heparinoid (Eleparon). None of the preparations caused a significant direct aggregation. The collagen-induced aggregation was inhibited by all mentioned preparations; thereby the heparins proved to be effective approx. to the same degree whereas the heparinoid proved to be significantly less effective. The ADP-induced aggregation was potentiated by all preparations. A considerably different sensitivity to heparin could be observed in the single PRP's. A special method was found out to exclude the influence of the heparin-sensitivity of the PRP's to compare the special effects of the heparins.
Zusammenfassung
Es wurde die Wirkung von 4 Heparinpräparationen (Novo, Vitrum, Liquemin, Hämoderivate) und einem Heparinoid (Eleparon) auf die ADP- und Kollagen-induzierte Plättchenaggregation in vitro an plättchenreichem Plasma gesunder Probanden getestet. Keine der Präparationen bewirkte eine signifikante direkte Plättchenaggregation. Die Kollagen-induzierte Aggregation wurde von allen Präparationen gehemmt, wobei die Heparinpräparate ungefähr gleich wirksam waren, während das Heparinoid signifikant weniger wirksam war. Die ADP-induzierte Aggregation wurde von allen Präparationen gefördert. Es zeigte sich an den einzelnen plättchenreichen Plasmen eine beträchtlich unterschiedliche Heparinsensitivität. Es wurde ein spezielles Verfahren ausgearbeitet, um bei Wirkungsvergleich den Einfluß der Heparinsensitivität des plättchenreichen Plasmas auszugleichen.
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Kronik, G., Deutsch, E. Die Beeinflussung der Kollagen-induzierten Plättchen-Aggregation durch fünf käuflich erhältliche Heparinpräparate. Blut 35, 363–372 (1977). https://doi.org/10.1007/BF00996622
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DOI: https://doi.org/10.1007/BF00996622