Tosylation of the nitrogenous components of nucleic acids

  • Z. A. Martirosyan
  • V. I. Gunar
  • S. I. Zav'yalov
Organic and Biological Chemistry


  1. 1.

    The interaction of uracil and adenine with p-toluenesulfonyl chloride in pyridine leads to the corresponding 1- and 9-tosyl derivatives, which are also formed in the tosylation of 2,4-bis(trimethylsilyloxy)-pyrimidine and 6-(trimethylsilylamino)-9-(trimethylsilyl)purine.

  2. 2.

    In the reaction of 5-(hydroxymethyl)-uracil with p-toluenesulfonyl chloride in pyridine, 5-(pyridini-ummethyl) uracil is obtained.



Chloride Nucleic Acid Pyridine Adenine Pyrimidine 
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Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • Z. A. Martirosyan
    • 1
  • V. I. Gunar
    • 1
  • S. I. Zav'yalov
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRUSSR

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