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Sex difference and the influence of endotoxin and hypertransfusion in spleen colony formation

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Summary

Lethally whole-body irradiated mice upon receiving a relatively small quantity of marrow cells show a distinct sex difference in ability to support colony formation in spleen and cell proliferation in femoral marrow. The difference should be defined with reference to the organ in question. Female mice manifest more efficient splenic haematopoiesis while among the males myeloid haematopoiesis, as measured by59Fe and125IUdR incorporation, seems to be greater. Endotoxin treatment and hypertransfusion exert profound influences, interacting with the sex-hormonal status of the animal.

Zusammenfassung

Letal ganzkörperbestrahlte Mäuse zeigen nach Erhalt einer relativ kleinen Menge syngeneischer Knochenmarkzellen einen deutlichen geschlechtsabhängigen Unterschied bei der Bildung von Milzkolonien und bei der Zell-Proliferation im Femurmark. Weibliche Mäuse zeigen eine effizientere Hämatopoese in der Milz, während bei den männlichen Tieren die myeloische Hämatopoese zu überwiegen scheint, wie durch Incorporation von59Fe und125IUdR gemessen wurde. Eine Behandlung mit Endotoxin und eine Hypertransfusion haben einen starken Einfluß in Wechselwirkung mit dem Geschlechtshormon-Status der Tiere.

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Author notes

  1. Abraham F. G. Stevenson

    Present address: Laboratorium für experimentelle Radiologie, Ingolstädter Landstraße 2, 8042, Neuherberg bei München, Germany

Authors and Affiliations

  1. Unité INSERM-117, Fondation Bergonié, Bordeaux, France

    Abraham F. G. Stevenson & Jean-Francois Duplan

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  1. Abraham F. G. Stevenson
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Stevenson, A.F.G., Duplan, JF. Sex difference and the influence of endotoxin and hypertransfusion in spleen colony formation. Blut 32, 361–370 (1976). https://doi.org/10.1007/BF00996476

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