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Leukozyten- und Erythrozyten-lnteraktion mit Kollagen in vitro: Eine rasterelektronenmikroskopische Untersuchung

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Zusammenfassung

An Hand rasterelektronenmikroskopischer Bilder wird gezeigt, da\ eine Interaktion von Leukozyten und Erythrozyten mit fibrillÄrem und polymerisierendem (Typ I und III) Kollagen möglich ist und unter bestimmten Testbedingungen beobachtet werden kann. Eine mögliche pathogenetische Bedeutung der Kollagen-,Leukozyten- und Erythrozyten-Interaktion wird diskutiert.

Summary

Scanning microscopic investigations show the interaction of Leukocytes and Erythrocytes with fibrillar and aggregating type I and type III collagens in vitro. Leukocytes, in the presence of collagen, form loose aggregates within a minute and these aggregates, after 15 to 30 minutes, coalesce and become compact. The close association of the fibrillar collagens to the leukocyte surfaces is shown. Fibrillar collagen and collagen in solution with erythrocytes form only loose aggregates. Qualitative differences between the various collagen preparations were not found. The pathogenetic implications of these observations are briefly discussed.

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Author notes

  1. Leopold Balleisen

    Present address: Lehrstuhl für Innere Medizin, speziell HÄmatologie, der UniversitÄt München, Deutschland

Authors and Affiliations

  1. Lehrstuhl für Innere Medizin, speziell HÄmatologie, der UniversitÄt München, Deutschland

    Rudolf Marx

Authors
  1. Leopold Balleisen
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  2. Rudolf Marx
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Additional information

Diese Untersuchungen wurden vom Sonderforschungsbereich 51 (Medizinische Molekularbiologie und Biochemie in München) unterstützt.

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Balleisen, L., Marx, R. Leukozyten- und Erythrozyten-lnteraktion mit Kollagen in vitro: Eine rasterelektronenmikroskopische Untersuchung. Blut 32, 185–193 (1976). https://doi.org/10.1007/BF00995912

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  • DOI: https://doi.org/10.1007/BF00995912

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