Journal of Chemical Ecology

, Volume 8, Issue 5, pp 837–842 | Cite as

Toxicity studies of analogs of 2-tridecanone, a naturally occurring toxicant from a wild tomato

  • Michael B. Dimock
  • George G. Kennedy
  • William G. Williams


Toxicity bioassays of the naturally occurring insecticide 2-tridecanone and a group of structural analogs against the tomato fruitworm (Heliothis zea) reveal a significant influence of chain length on toxicity of methyl ketones. This effect may be due to the differential ability of these compounds to penetrate lipid barriers and reach the active site, since a close relationship is seen between toxicity and lipophilicity. Congeners of chain lenths 15 and over are less active than predicted by this relationship, possibly due to steric effects.

Key words

2-Tridecanone structure-activity relationships Lycopersicon hirsutum f.glabratum C.M. Mull Heliothis zea (Boddie) Lepidoptera Noctuidae resistance 


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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Michael B. Dimock
    • 1
  • George G. Kennedy
    • 1
  • William G. Williams
    • 2
  1. 1.Department of EntomologyNorth Carolina State UniversityRaleigh
  2. 2.Department of ChemistryNorth Carolina State UniversityRaleigh

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