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Neurochemical Research

, Volume 12, Issue 4, pp 315–321 | Cite as

Day-night cycle of lipidic composition in rat cerebral cortex

  • Mauricio Díaz-Muñoz
  • Jorge Suárez
  • Rolando Hernández-Muñoz
  • Victoria Chagoya de Sánchez
Original Articles

Abstract

A study of the lipidic pattern of the cerebral cortex of the normal adult rat during the daynight cycle was carried out. The changes observed were the following: phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine plus phosphatidic acid showed a peak at 16:00 hr possibly due to a general increase in phospholipid biosynthesis. During the nocturanl period the variations of phosphatidylcholine and phosphatidylethanolamine were not clearly observe, they might be due to an increase in the interconversion or exchange reaction, since the ratio phosphatidylcholine/phosphatidylethanolamine showed a significative change at 04:00 hr. This occurred because small but opposite changes in both phospholipids were observed, suggesting an increase in the methylation reactions of phospholipids. Cardiolipin showed a significant peak at 04:00 hr. Plasmalogens exhibited significative changes, an important diminution at 16:00 hr and a prominent peak at 24:00 hr. Cholesterol levels were high during the light period and low in the dark one. Cerebrosides and gangliosides showed no day-night variations. The changes observed indicate a phenomenon of biological rhythmicity synchronized by the photoperiod, suggesting that these fluctuations could act as physiological modulators of the properties and functions of the nerve cell membrane.

Key Words

Day-night cycle brain lipids cerebral cortex 

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Mauricio Díaz-Muñoz
    • 1
  • Jorge Suárez
    • 1
  • Rolando Hernández-Muñoz
    • 1
  • Victoria Chagoya de Sánchez
    • 1
  1. 1.Departamento de Bioenergética, Instituto de Fiosiología CelcularUniversidad Nacional Autónoma de MéxicoMéxicoMexico

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