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The RNase P ofDictostyelium discoideum

  • Special Issue: RNase MRP/RNase P Systems
  • RNase P
  • Published:
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Abstract

Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5′-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase P RNA is the only known RNA enzyme which functionsin trans in nature. Similar behaviour has not been demonstrated in RNase P enzymes examined from archaebacteria or eukaryotes. Characterisation of RNase P enzymes from more diverse eukaryotic species, including the slime moldDictyostelium discoideum, is useful for comparative analysis of the structure and function of eukaryotic RNase P.

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Abbreviations

RNase P:

ribonuclease P

MN:

micrococcal nuclease

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, University of Patras, 26500, Rio-Patras, Greece

    Denis Drainas

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  1. Denis Drainas
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Drainas, D. The RNase P ofDictostyelium discoideum . Mol Biol Rep 22, 135–138 (1995). https://doi.org/10.1007/BF00988718

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