Abstract
In addition to the m7G cap structure, the length of the 5′ UTR and the position and context of the AUG initiator codon (which have been discussed elsewhere in this volume), higher order structures within mRNA represent a critical parameter for translation. The role of RNA structure in translation initiation will be considered primarily, although structural elements have also been found to affect translation elongation and termination. We will first describe the different effects of higher order RNA structuresper se, and then consider specific examples of RNA structural elements which control translation initiation by providing binding sites for regulatory proteins.
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References
Kozak M (1986) Proc. Natl. Acad. Sci. USA 83: 2850–2854
Pelletier J & Sonenberg N (1985) Cell 40: 515–526
Kozak M (1989) Mol. Cell. Biol. 9: 5134–5142
Lawson TG, Ray BK, Dodds, JT, Abramson RD, Merrick WC, Betsch DF, Weith HL & Thach RE (1986) J. Biol. Chem. 261: 13979–13989
Pelletier J & Sonenberg N (1985) Mol. Cell. Biol. 5: 3222–3230
Rozen F, Edery I, Meerovitch K, Dever TE, Merrick WC & Sonenberg N (1990) Mol. Cell. Biol. 10: 1134–1144
Koromilas, AE, Lazaris-Karatzas A & Sonenberg N (1992) EMBO J. 11: 4153–4150
Hiremath LS, Webb NR & Rhoads RE (1985) J. Biol. Chem. 260: 7843–7849
Duncan R, Milburn SC & Hershey JWB (1987) J. Biol. Chem. 262: 380–388
Merrick WC (1992) Microbiol. Rev. 56: 291–315
Lazaris-Karatzas A, Montine KS & Sonenberg N (1990) Nature 345: 544–547
Smith MR, Jaramillo M, Liu Y, Dever TE, Merrick WC, Kung H & Sonenberg N (1990) New Biol. 2: 648–654
Rosenwald IB, Lazaris-Karatzas A, Sonenberg N & Schmidt EV (1993) Mol. Cell Biol. 13: 7358–7363
Gulyas KD & Donahue TF (1992) Cell 69: 1031–1042
Yoon H, Miller SP, Pabich EK & Donahue TF (1992) Genes & Dev. 6: 2463–2477
Altmann M, Müller PP, Wittmer B, Ruchti F, Lanker S & Trachsel H (1993) EMBO J. 12: 3997–4003
Bootsma D & Hoeijmakers JHJ (1993) Nature 363: 114–115
Kozak M (1991) J. Biol. Chem. 266: 19867–19870
Rao CD, Pech M, Robbins KC & Aaronson SA (1988) Mol. Cell. Biol. 8:284–292
Grens A & Scheffler IE (1990) J. Biol. Chem. 265: 11810–11816
Manzella JM & Blackshear PJ (1990) J. Biol. Chem. 265: 11817–11822
Johannes G & Berger FG (1992) J. Biol. Chem. 267: 10108–10115
Ito K, Kashiwagi K, Watanabe S, Kameji T, Hayashi S & Igarashi K (1990) J. Biol. Chem. 265: 13036–13041
Spena A, Krause E & Dobberstein B (1985) EMBO J. 4: 2153–2158
Kozak M (1990) Proc. Natl. Acad. Sci. USA 87: 8301–8305
Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB & Klausner RD (1987) Science 238: 1570–1573
Aziz N & Munro HN (1987) Proc. Natl. Acad. Sci. USA 84: 8478–8482
Melefors Ö, Goossen B, Johansson HE, Stripecke R, Gray NK & Hentze MW (1993) J. Biol. Chem. 268: 5974–5978
Klausner RD, Rouault T & Harford JB (1993) Cell 72: 19–28
Gray NK, Quick S, Goossen B, Constable A, Hirling H, Kühn LC & Hentze MW (1993) Eur. J. Biochem. 218: 657–667
Goossen B & Hentze MW (1992) Mol. Cell. Biol. 12: 1959–1966
Stripecke R & Hentze MW (1992) Nucl. Acids Res. 20: 5555–5564
Chu E, Voeller D, Koeller DM, Drake JC, Takimoto CH, Maley GF, Maley F & Allegra CJ (1993) Proc. Natl. Acad. Sci. USA 90: 517–521
Chu E, Takimoto CH, Voeller D, Grem JL & Allegra CJ (1993) Biochemistry 32: 4756–4760
Kuhn R, Kuhn C, Borsch D, Glätzer KH, Schäfer U & Schäfer M (1991) Mech. Dev. 35: 143–151
Amaldi F, Bozzoni I, Beccari E & Pierandrei-Amaldi P (1989) Trends Biochem. 14: 175–178
Levy S, Avni D, Hariharan N, Perry RP & Meyuhas O (1991) Proc. Natl. Acad. Sci. USA 88: 3319–3323
Kaspar RL, Kakegawa T, Cranston H, Morris DR & White MW (1992) J. Biol. Chem. 267: 508–514
Hammond ML, Merrick W & Bowman LH (1991) Genes & Dev. 5: 1723–1736
Cardinali B, Di Cristina M & Pierandrei-Amaldi P (1993) Nucl. Acids Res. 21: 2301–2308
Fleming J, Thiele BJ, Chester J, O'Prey J, Janetzki S, Aitken A, Anton IA, Rapoport SM & Harrison PR (1989) Gene 79: 181–188
Ostareck-Lederer A, Ostareck DH, Standart N & Theile BJ (1994) EMBO 13: 1476–1481
Goodwin EB, Okkema PG, Evans TC & Kimble J (1993) Cell 75: 329–339
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Gray, N.K., Hentze, M.W. Regulation of protein synthesis by mRNA structure. Mol Biol Rep 19, 195–200 (1994). https://doi.org/10.1007/BF00986961
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DOI: https://doi.org/10.1007/BF00986961