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European Journal of Clinical Pharmacology

, Volume 31, Issue 3, pp 351–353 | Cite as

Digoxin-diltiazem interaction: A pharmacokinetic evaluation

  • W. N. Jones
  • K. B. Kern
  • J. P. Rindone
  • M. Mayersohn
  • M. Bliss
  • S. Goldman
Originals

Summary

The pharmacokinetics of digoxin were studied before and after a 2 week course of diltiazem, 30 mg four times daily, in 7 healthy volunteers. Each subject received an IV dose of digoxin before starting diltiazem and again on day 15 of the study. Diltiazem was continued until all sera and urine were collected. During the control and diltiazem phases, respectively, the terminal elimination rate constants were 0.0231±0.007 h−1 and 0.0254±0.007 h−1, the volumes of distribution were 10.5±3.95 l/kg and 10.2±3.26 l/kg, and the total body clearances were 3.72±0.78 ml·min−1·kg−1 and 4.09±0.94 ml·min−1·kg−1. None of these pharmacokinetic parameters of digoxin were significantly different before or during diltiazem administration. Overall, there does not appear to be an interaction between digoxin and diltiazem.

Key words

digoxin diltiazem interaction pharmacokinetics 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • W. N. Jones
    • 1
    • 3
    • 4
    • 7
  • K. B. Kern
    • 2
    • 3
    • 6
    • 8
  • J. P. Rindone
    • 5
  • M. Mayersohn
    • 3
    • 7
  • M. Bliss
    • 3
    • 7
  • S. Goldman
    • 2
    • 3
    • 6
    • 8
  1. 1.Pharmacy ServiceThe University of ArizonaTucsonUSA
  2. 2.Department of Internal MedicineThe University of ArizonaTucsonUSA
  3. 3.Veterans Administration Medical CenterThe University of ArizonaTucsonUSA
  4. 4.Department of Pharmacy PracticeThe University of ArizonaTucsonUSA
  5. 5.Department of Pharmaceutical ScienceThe University of ArizonaTucsonUSA
  6. 6.Department of Internal MedicineThe University of ArizonaTucsonUSA
  7. 7.College of PharmacyThe University of ArizonaTucsonUSA
  8. 8.College of MedicineThe University of ArizonaTucsonUSA

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