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The effect ofl-deprenyl on behavior, cognitive function, and biogenic amines in the dog

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Abstract

Behavioral and pharmacological effects of oral administration ofl-deprenyl in the dog are described. Spontaneous behavior is unaffected at doses below 3 mg/kg while at higher doses there was stereotypical responding. There was evidence of improved cognitive function in animals chronically treated with a 1 mg/kg dose but the effectiveness varied considerably between subjects. Chronic administration produced a dose dependent inhibition in brain, kidney and liver monoamine oxidase B, and had no effect on monoamine oxidase A. There were also dose dependent increases in brain phenylethylamine and in plasma levels of amphetamine. Dog platelets did not have significant levels of MAO-B. Brain dopamine and serotonin metabolism were unaffected byl-deprenyl at doses up to 1 mg/kg. It appears that for the dog, deamination of catecholamines is controlled by MAO-A. Nevertheless, it is suggested thatl-deprenyl serves as a dopaminergic agonist, and there is also evidence that it affects adrenergic transmission. These catecholaminergic actions may account for the effects ofl-deprenyl on behavior and cognitive function.

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Authors and Affiliations

  1. Life Science Division, Scarborough Campus, University of Toronto, 1265 Military Trail, M1C1A4, Scarborough, Ontario, Canada

    N. W. Milgram, G. O. Ivy, E. Head & M. P. Murphy

  2. Department of Pharmacology, University of Toronto, M151A8, Toronto, Ontario, Canada

    P. H. Wu

  3. Deprenyl Animal Health Inc., 66210, Overland Park, Kansas

    W. W. Ruehl

  4. Neuropsychiatric Research, Department of Psychiatry, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada

    P. H. Yu, D. A. Durden, B. A. Davis, I. A. Paterson & A. A. Boulton

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  1. N. W. Milgram
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Milgram, N.W., Ivy, G.O., Head, E. et al. The effect ofl-deprenyl on behavior, cognitive function, and biogenic amines in the dog. Neurochem Res 18, 1211–1219 (1993). https://doi.org/10.1007/BF00975038

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