Polymer Bulletin

, Volume 32, Issue 5–6, pp 509–515 | Cite as

Incorporation of salicylates into poly(l-lactide)

  • H. Supèr
  • D. W. Grijpma
  • A. J. Pennings
Article

Summary

Recent studies have indicated that complications like swelling and inflammation of the surrounding tissue may occur in the late stage of thein vivo degradation of semi-crystalline PLLA bone fixation devices. Incorporation of an anti-inflammatory drug, like a salicylate, in the poly(L-lactide) chain might be a route to prevent these complications. In this study, it has been shown that it is possible to copolymerize L-lactide with di- and trisalicylide and to use salicylic acid as an initiator for the L-lactide polymerization or the L-lactide/ε-caprolactone copolymerization. Furthermore, PLLA was blended with poly(salicylic acid) and Zn(salicylate)2 was synthesized and turned out to be a catalyst for the ring opening polymerization of L-lactide. The binary poly(L-lactide)/o-acetyl salicylic acid system has an eutectic composition for 52 % w/w of poly(L-lactide) in the mixture. Its eutectic melting temperature is 119 °C.

Keywords

Salicylic Acid Copolymerization Salicylate PLLA Surrounding Tissue 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. Supèr
    • 1
  • D. W. Grijpma
    • 1
  • A. J. Pennings
    • 1
  1. 1.Department of Polymer ChemistryUniversity of GroningenGroningenThe Netherlands

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