Polymer Bulletin

, Volume 32, Issue 5–6, pp 509–515 | Cite as

Incorporation of salicylates into poly(l-lactide)

  • H. Supèr
  • D. W. Grijpma
  • A. J. Pennings


Recent studies have indicated that complications like swelling and inflammation of the surrounding tissue may occur in the late stage of thein vivo degradation of semi-crystalline PLLA bone fixation devices. Incorporation of an anti-inflammatory drug, like a salicylate, in the poly(L-lactide) chain might be a route to prevent these complications. In this study, it has been shown that it is possible to copolymerize L-lactide with di- and trisalicylide and to use salicylic acid as an initiator for the L-lactide polymerization or the L-lactide/ε-caprolactone copolymerization. Furthermore, PLLA was blended with poly(salicylic acid) and Zn(salicylate)2 was synthesized and turned out to be a catalyst for the ring opening polymerization of L-lactide. The binary poly(L-lactide)/o-acetyl salicylic acid system has an eutectic composition for 52 % w/w of poly(L-lactide) in the mixture. Its eutectic melting temperature is 119 °C.


Salicylic Acid Copolymerization Salicylate PLLA Surrounding Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. Supèr
    • 1
  • D. W. Grijpma
    • 1
  • A. J. Pennings
    • 1
  1. 1.Department of Polymer ChemistryUniversity of GroningenGroningenThe Netherlands

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