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Neurochemical Research

, Volume 13, Issue 7, pp 633–635 | Cite as

Lack of physiological stimulation induces decreased proteolytic activity in nerve terminals

  • S. Gustavsson
  • J. -O. Karlsson
Original Articles

Abstract

The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decreased degradation of slowly transported labeled proteins in the nerve terminals in the superior colliculus.

Key Words

Nerve activity proteolysis 

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References

  1. 1.
    Karlsson, J.-O., and Sjöstrand, J. 1972. Axonal transport in retinal ganglion cells. Characterization of the transport to the superior colliculus. Brain Res. 47:185–194.Google Scholar
  2. 2.
    Willard, M., Cowan, W. M., and Vagelos, P. R. 1974. The polypeptide composition of intra-axonally transported proteins: evidence for four transport velocities., Proc. Natl. Acad. Sci. U.S.A. 71:2183–2187.Google Scholar
  3. 3.
    Gustavsson, S., and Karlsson, J.-O. 1986. In situ degradation of rapidly transported proteins in nerve terminals of retinal ganglion cells. Neurosci. Lett. 63:221–224.Google Scholar
  4. 4.
    Karlsson, J.-O. 1977. Is there an axonal transport of amino acids? J. Neurochem. 29:615–617.Google Scholar
  5. 5.
    Karlsson, J.-O., and Sjöstrand, J. 1971. Synthesis, migration and turnover of protein in retinal ganglion cells. J. Neurochem. 18:749–767.Google Scholar
  6. 6.
    Karlsson, J.-O., and Sjöstrand, J. 1968. Transport of labeled proteins in the optic nerve and tract of the rabbit. Brain Res. 11:431–439.Google Scholar
  7. 7.
    Ochs, S. 1972. Fast transport of materials in mammalian nerve fibers. Science 176:252–260.Google Scholar
  8. 8.
    Karlsson, J.-O. 1984. Axonal transport in retinal ganglion cells. Pages 105–121,in N. Osborne and J. Chader (eds.), Progress in Retinal Research, Pergamon Press, Oxford and New York.Google Scholar
  9. 9.
    Sandberg, M., Hamberger, A., Jacobson, I., and Karlsson, J.-O. 1980. The role of calcium ions in the formation and release of small molecular weight substances from optic nerve terminals. Neurochem. Res. 5:1185–1198.Google Scholar
  10. 10.
    Sandberg, M., Hamberger, A., Karlsson, J.-O., and Tirillini, B. 1980. Potassium-stimulated release of axonally transported radioactivity from slices of rabbit superior colliculus. Brain Res. 188:175–183.Google Scholar
  11. 11.
    Andersson, K. E., and Edström, A. 1973. Effects of nerve blocking agents and fast axonal transport of proteins in frog sciatic nerves in vitro. Brain Res. 50:125–134.Google Scholar
  12. 12.
    Edwards, D. L., and Grafstein, B. 1984. Intraocular tetrodotoxin in goldfish decreases fast axonal transport of [3H]glucosamine-labeled materials in optic axons. Brain Res. 299:190–194.Google Scholar
  13. 13.
    Riccio, R. V., and Matthews, M. A. 1985. The effect of intraocular injection of tetrodotoxin on fast axonal transport of [3H]proline-and [3H]fucoselabeled materials in the developing rat optic nerve. Neuroscience 16:1027–1039.Google Scholar
  14. 14.
    Edwards, D. L., and Grafstein, B. 1986. Intraocular tetrodotoxin reduces axonal transport and transcellular transfer of adenosine and other nucleosides in the visual system of goldfish. Brain Res. 364:258–267.Google Scholar
  15. 15.
    Schubert, P., Rose, G., Lee, K., and Kreutzberg, G. 1977. Axonal release and transfer of nucleoside derivates in the enthorhinal-hippocampal system: an autoradiographic study. Brain Res. 134:347–352.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • S. Gustavsson
    • 1
  • J. -O. Karlsson
    • 1
  1. 1.Institue of NeurobiologyUniversity of GöteborgGöteborgSweden

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