Abstract
Calorimetric studies of the inclusion complexes of straight and branched alcohols and of diols with alpha-cyclodextrin (α-CD) have been carried out in water solvent. The data suggest that straight and branched chain alcohols enter the cavity of α-CD alkyl end first. The hydroxyl group hydrogen bonds to the outer oxygen ring of the cyclodextrin. For branched chain alcohols the longer alkyl part of the molecule penetrates the α-CD cavity up to the hydroxyl group. Diols form two hydrogen bonds to the outer oxygen ring of the cyclodextrin with some penetration into its interior.
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Spencer, J.N., DeGarmo, J., Paul, I.M. et al. Inclusion complexes of alcohols with α-cyclodextrin. J Solution Chem 24, 601–609 (1995). https://doi.org/10.1007/BF00973210
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DOI: https://doi.org/10.1007/BF00973210