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Effects of linalool on glutamatergic system in the rat cerebral cortex

Neurochemical Research volume 20, pages 461–465 (1995)Cite this article

Abstract

Linalool is a monoterpene compound reported to be a major component of essential oils in, various aromatic species. Several Linalool-producing species are used in traditional medical systems, includingAeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.

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Authors and Affiliations

  1. Laboratório de Etnofarmacologia, Depto de Farmacologia, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa Postal 5072, 90041-970, Porto Alegre, RS, Brazil

    Elaine Elisabetsky & Jeanine Marschner

  2. Depto de Bioquímica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Diogo Onofre Souza

Authors
  1. Elaine Elisabetsky
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  2. Jeanine Marschner
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  3. Diogo Onofre Souza
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Elisabetsky, E., Marschner, J. & Onofre Souza, D. Effects of linalool on glutamatergic system in the rat cerebral cortex. Neurochem Res 20, 461–465 (1995). https://doi.org/10.1007/BF00973103

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  • DOI: https://doi.org/10.1007/BF00973103

Key Words

  • Glutamate
  • anticonvulsant
  • Linalool
  • binding