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Neurochemical Research

, Volume 20, Issue 4, pp 461–465 | Cite as

Effects of linalool on glutamatergic system in the rat cerebral cortex

  • Elaine Elisabetsky
  • Jeanine Marschner
  • Diogo Onofre Souza
Original Articles

Abstract

Linalool is a monoterpene compound reported to be a major component of essential oils in, various aromatic species. Several Linalool-producing species are used in traditional medical systems, includingAeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.

Key Words

Glutamate anticonvulsant Linalool binding 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Elaine Elisabetsky
    • 1
  • Jeanine Marschner
    • 1
  • Diogo Onofre Souza
    • 2
  1. 1.Laboratório de Etnofarmacologia, Depto de Farmacologia, Instituto de BiociênciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Depto de Bioquímica, Instituto de BiociênciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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