Neurochemical Research

, Volume 20, Issue 4, pp 461–465 | Cite as

Effects of linalool on glutamatergic system in the rat cerebral cortex

  • Elaine Elisabetsky
  • Jeanine Marschner
  • Diogo Onofre Souza
Original Articles


Linalool is a monoterpene compound reported to be a major component of essential oils in, various aromatic species. Several Linalool-producing species are used in traditional medical systems, includingAeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.

Key Words

Glutamate anticonvulsant Linalool binding 


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  1. 1.
    Foster, G. M. 1976. Disease etiologies in non-western medical systems. American Anthropologist 78:773–782.Google Scholar
  2. 2.
    Farnsworth, N. R. 1988. Screening plants for new medicines. Pages 83–97,in Wilson, E. O. and Peter, F. M. (eds.), Biodiversity, National Academic Press, Washington DC, Chapter 9.Google Scholar
  3. 3.
    Adesina, S. K. 1982. Studies on some plants used as anticonvulsants in Ameridian and African traditional medicine. Fitoterapia 53(5–6):147–162.Google Scholar
  4. 4.
    Chauhan, A. K., Dobhal, M. P., and Joshi, B. C. 1988. A review of medicinal plants showing anticonvulsant activity. J. Ethnopharm. 22:11–23.Google Scholar
  5. 5.
    Elisabetsky, E., and Setzer, R. 1986. Caboclo concepts of disease, diagnosis and therapy: implications for ethnopharmacology and health systems in Amazonia. Pages 243–278,in Parker, E. P. (ed.). The Amazon Caboclo: historical and contemporary perspectives, Studies on Third World Societies, Vol. 32.Google Scholar
  6. 6.
    Elisabetsky, E., Souza, G. P. C., Santos, M. A. C., Siqueira, I. R., and Amador, T. A. 1994. Sedative properties of Linalool. Fitoterapia, submitted.Google Scholar
  7. 7.
    Collingridge, G. L., and Lester, R. A. 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40(2):143–208.Google Scholar
  8. 8.
    Fonnum, F. 1984. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42:1–11.Google Scholar
  9. 9.
    Gasic, G. P., and Heinemann, S. 1991. Receptors coupled to ionic channels: the glutamate receptor family. Cur. Opin. Neurobiol. 1:20–26.Google Scholar
  10. 10.
    Schoepp, D. D., and Conn, P. J. 1993. Metabotropic glutamate receptors in brain function and pathology. TIPS 14:13–20.Google Scholar
  11. 11.
    Swinyard, E. A., White, H. S., and Wolf, H. H. 1988. Mechanisms of Anticonvulsant Drugs. ISI Atlas of Science: Pharmacology. 2:95–98.Google Scholar
  12. 12.
    Meldrum, B. S. 1990. Mechanism based approaches to anticonvulsant therapies: modulation of inhibitory and excitatory transmission. Pages 31–43,in Meldrum, B. S. and Williams, M. (eds.), Current and future trends in anticonvulsant, anxiety and stroke therapy: proceedings of a symposium held at Princeton, New Jersey. Wiley-Liss, Inc. New York.Google Scholar
  13. 13.
    Cotman, C. W., and Iversen, L. L. 1987. Excitatory amino acids in the brain-focus on NMDA receptors. TINS 10(7):263–265.Google Scholar
  14. 14.
    Hepler, J. R., and Gilman, A. G. 1992. G proteins. Trends Pharmacol. Sci. 17:383–387.Google Scholar
  15. 15.
    Birnbaumer, L., Abramowitz, J., and Brown, A. M. 1990. Receptor-effector coupling by G proteins. Bioch. Biophys. Acta. 1031:163–224.Google Scholar
  16. 16.
    Brown, A. M. 1993. Membrane-delimited cell signaling complexes: direct ion channel regulation by G proteins. J. Membrane Biol. 131:93–104.Google Scholar
  17. 17.
    Souza, D. O., and Ramirez, G. 1991. Effects of guanine nucleotides on kainic acid binding and on Adenylate cyclase in chick optic tectum and cerebellum. J. Mol. Neurosci. 3:39–45.Google Scholar
  18. 18.
    Albano, J. D. M., Barnes, G. D., Naudsley, D. V., Brown, B. L., and Ekins, R. P. 1974. Factors affecting the saturation assay of cyclic AMP in biological systems. Anal. Biochem. 60:130–141.Google Scholar
  19. 19.
    Tovey, K. C., Oldham, K. G., and Whelam, J. A. M. 1974. A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique. Clin. Chim. Acta. 56:221–234.Google Scholar
  20. 20.
    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.Google Scholar
  21. 21.
    Samuelsson, G. 1989. Nature as a source of new drugs. Acta. Pharm. Nord. 1(3):111–116.Google Scholar
  22. 22.
    Carlini, E. A., Contar, J. D. P., Silva-Filho, A. R., Silveira-Filho, N., Frochtengarten, M. L., and Bueno, O. F. A. 1986. Pharmacology of lemongrass (Cymbopogon citratus Stapf.). I. Effects of teas prepared from the leaves on laboratory animals. J. Ethnopharm. 17:37–64.Google Scholar
  23. 23.
    Santos, C. A. M., Torres, K. R., and Leonarst, R. 1988. Plantas medicinais (herbarium, Flora et scientia). Editora Icone. São Paulo, Brazil.Google Scholar
  24. 24.
    Elisabetsky, E., and Castilhos, Z. C. 1990. Plants used as analgesics by Amazonian caboclos as a basis for selecting plants for investigation. Int. J. Crude Drug Res. 28(4):49–60.Google Scholar
  25. 25.
    Wannamacher, L., Fuchs, F. D., Paoli, C. I., Gianupi, A., Fillmann, H. S., Hasegawa, C. Y., Ribeiro, A. M. S., Muller, A. L., Lanca, E., and Marques, A. 1990. Plants employed in the treatment of anxiety and insomnia. I. An ethnopharmacological survey in Porto Alegre, Brazil. Fitoterapia. 16:445–448.Google Scholar
  26. 26.
    Sweetnam, P. M., Caldwell, L., Lancaster, J., Bauer, Jr., C., McMillan, B., Kinnier, w. J., and Price, C. H. 1993. The role of receptor binding in drug discovery. J. Nat. Prod. 56(4):441–455.Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Elaine Elisabetsky
    • 1
  • Jeanine Marschner
    • 1
  • Diogo Onofre Souza
    • 2
  1. 1.Laboratório de Etnofarmacologia, Depto de Farmacologia, Instituto de BiociênciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Depto de Bioquímica, Instituto de BiociênciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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