Neurochemical Research

, Volume 13, Issue 4, pp 325–328 | Cite as

Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated

  • Michael T. Ivy
  • Paul T. Carroll
Original Articles


The effect ofl- andd-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (Ach) from rat hippocampal tissue was studied.l-AH 5183 was approximately 100 times more potent than wasd-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.

Key Words

ACh release rat hippocampus carrier-mediated AH 5183 stereoisomers 


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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Michael T. Ivy
    • 1
  • Paul T. Carroll
    • 1
  1. 1.Department of PharmacologyTexas Tech University Health Sciences CenterLubbock

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