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Detoxification enzymes following intrastriatal kainic acid

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Abstract

A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished. An enhancement of the specific activities of glutathione peroxidase (GP) and catalase is found without an alteration in the specific activity of superoxide dismutase (SOD). There is no increase in the in vivo striatal levels of malondialdehyde, a putative indicator of lipid peroxidation, the expected result of cell membrane damage from oxygen metabolites. Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study.

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Authors and Affiliations

  1. Ensor Research Laboratory, William S. Hall Psychiatric Institute, Post Office Box 202, 29202, Columbia, South Carolina

    Martin R. Cohen M.D., C. N. Ramchand, Voyta Sailer, Maria Fernandez, William McAmis, N. Sridhara & Cornelius Alston

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, 29202, Columbia, South Carolina

    Martin R. Cohen M.D.

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  1. Martin R. Cohen M.D.
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  2. C. N. Ramchand
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Cohen, M.R., Ramchand, C.N., Sailer, V. et al. Detoxification enzymes following intrastriatal kainic acid. Neurochem Res 12, 425–429 (1987). https://doi.org/10.1007/BF00972293

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