Neurochemical Research

, Volume 19, Issue 5, pp 575–580 | Cite as

Molecular cloning and characterization of avian N-methyl-d-aspartate receptor type1 (NMDA-R1) gene

  • Norio Kurosawa
  • Kazunori Kondo
  • Naohiro Kimura
  • Tomio Ikeda
  • Yasuzo Tsukada
Original Articles


Birds have several advantages in the study of memory formation, as imprinting and passive avoidance behaviors in chick are often used as model systems. However, the primary structure of the bird N-methyl-d-aspartate (NMDA) responsive glutamate receptor, which is assumed to play a critical role in memory formation, has not been determined. In this report we describe the cDNA cloning of a subunit of NMDA receptors (NMDA-R1) from duck and analysis of its structure and distribution in the brain. The N-terminal 898 amino acids of the NMDA-R1 were well conserved between duck and mammals, but the homology was completely lost in the C-terminus. In situ hybridization showed that the duck NMDA-R1 gene was expressed throughout the brain as it is in mammals.

Key Words

cDNA cloning duck N-methyl-d-aspartate receptor type1 in situ hybridization 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Norio Kurosawa
    • 1
  • Kazunori Kondo
    • 1
  • Naohiro Kimura
    • 1
  • Tomio Ikeda
    • 2
  • Yasuzo Tsukada
    • 2
  1. 1.Department of Bioenineering, Faculty of EngineeringSoka UniversityHachioji, TokyoJapan
  2. 2.Institute of Life ScienceSoka UniversityHachioji, TokyoJapan

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