Neurochemical Research

, Volume 12, Issue 8, pp 745–749 | Cite as

Aging: Effect on ex-vivo benzodiazepine binding after a diazepam injection

  • H. L. Komiskey
Original Articles


Ex vivo [3H]flunitrazepam receptor occupation was determined in the brain of young, mature and old male Fischer 344 rats after a single intravenous injection of a low dose of diazepam. The two benzodiazepine receptor subtypes or conformations (BZ1 and BZ2) were differentiated by the displacement of [3H]flunitrazepam specific binding with the triazolopyridazine, CL 218,872. The acute diazepam injection decreased ex vivo [3H]flunitrazepam binding in only the senescent rats. The [3H]flunitrazepam binding at both the BZ1 and BZ2 receptor or receptor conformation was significantly reduced in the old rats.

Key Words

Aging ex vivo benzodiazepine binding diazepam rat brain 


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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • H. L. Komiskey
    • 1
  1. 1.Department of Biomedical SciencesUniversity of Illinois College of Medicine at RockfordRockford

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