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Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression

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Abstract

Studies from this laboratory have demonstrated that administration of the selective 5-HT2/1C antagonist LY53857 can block 5-HTP-induced response suppression. To further investigate the serotonergic mechanisms involved in this effect, we decided to test the capacity of LY53857 to block response suppression induced with two selective 5-HT agonists. After a 15 minute baseline period, rats trained to press a lever for milk reinforcement on a VI 1′ schedule were given IP injections of 1.0 mg/kg DOI, or 1.0 mg/kg 8-OH-DPAT to induce response suppression. Subsequently, rats were injected with 1.0 mg/kg LY53857 1 hour prior to DOI- or 8-OH-DPAT-induced response suppression. Preinjections with LY53857 resulted in a 100% blockade of DOI-induced response suppression whereas the same dose did not block response suppression induced with 8-OH-DPAT. These results indicate that the 5-HTP-induced response suppression shows some pharmacological similarity to DOI-induced response suppression and may be mediated through 5-HT2 and/or 5-HT1C receptors.

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Authors and Affiliations

  1. Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 46202-4887, Indianapolis, Indiana

    E. A. Engleman, J. M. Murphy & J. N. Hingtgen

  2. Department of Anatomy, Program in Medical Neurobiology, Institute of Psychiatric Research, Indiana University School of Medicine, 46202-4887, Indianapolis, Indiana

    F. C. Zhou

  3. Department of Psychology, Purdue School of Science, 46202-4887, Indianapolis, Indiana

    J. M. Murphy

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  1. E. A. Engleman
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  2. J. M. Murphy
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  3. F. C. Zhou
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  4. J. N. Hingtgen
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Special issue dedicated to Dr. Morris H. Aprison

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Engleman, E.A., Murphy, J.M., Zhou, F.C. et al. Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression. Neurochem Res 17, 483–488 (1992). https://doi.org/10.1007/BF00969896

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