Abstract
Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in El mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug administration. Glutamate levels were increased in the cerebrum, and glutamine levels were increased in the cerebellum three days after starting GES administration. Brain 5-HT levels were not changed at that time. These results suggest that increased seizure susceptibility induced by GES in mice is related to glutamatergic neurons.
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Hiramatsu, M., Edamatsu, R., Kabuto, H. et al. Increased seizure susceptibility induced by guanidinoethane sulfonate in El mice and its relation to glutamatergic neurons. Neurochem Res 14, 85–89 (1989). https://doi.org/10.1007/BF00969763
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DOI: https://doi.org/10.1007/BF00969763