Neurochemical Research

, Volume 20, Issue 7, pp 859–862 | Cite as

Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type

  • Ghislaine Le Prince
  • Pia Delaere
  • Christiane Fages
  • Thierry Lefrançois
  • Monique Touret
  • Marcelle Salanon
  • Marcienne Tardy
Original Articles

Abstract

Glutamine synthetase (GS), a metabolic marker of the mature astrocyte, was investigated in the temporal neocortex of postmortem brain samples of 8 cases, either not demented or affected by senile dementia of the Alzheimer type. A negative correlation between the GS protein level and the density of both classical βA4 deposits and senile plaques was evidenced. Such a correlation for GS underlies a dysfunction of the astroglial metabolism and particularly of the glutamate and ammonia neutralization. Since GS is sensitive to oxidative lesioning, the changes in GS level that were observed, occurring at the posttranslational stage, might reflect oxidative damage and have severe consequences on the pathological cascade of events.

Key Words

Blessed test score astrocyte classical senile plaque βA4 classical deposits 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Ghislaine Le Prince
    • 1
  • Pia Delaere
    • 2
  • Christiane Fages
    • 1
  • Thierry Lefrançois
    • 1
  • Monique Touret
    • 3
  • Marcelle Salanon
    • 3
  • Marcienne Tardy
    • 1
  1. 1.Inserm U 421, Faculté de MédecineHôpital Henri MondorCreteil cedexFrance
  2. 2.Laboratoire de Neuropathologie Raymond Escourolle, INSERM U 360, Association Claude BernardHôpital de la SalpêtrièreParis cedex 13France
  3. 3.Department de Médecine ExpérimentaleUniversité Claude BernardLyon cedex 08France

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