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Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse

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Abstract

In addition to an altered dopaminergic input, the striatum of the weaver mutant mouse (wv/wv) has increased serotonin tissue content and uptake compared to the wild-type mouse (+/+). To gain information regarding the functional status of serotonergic inputs to thewv/wv striatum, endogenous serotonin release fromwv/wv and +/+ striatum was measured under basal conditions as well as in the presence of fenfluramine or elevated concentrations of potassium (K+). Fractional basal release of serotonin from the +/+ striatum was significantly greater than that from thewv/wv striatum. In the presence of K+, evoked release (stimulated release minus basal release) was greater from the +/+ striatum than from thewv/wv striatum. In the presence of fenfluramine, evoked serotonin release was greater from thewv/wv striatum compared to the +/+ striatum. These data are consistent with the involvement of an additional transmitter(s) in modulating serotonin release to a greater extent in thewv/wv than the +/+ striatum. The data on fenfluramine-stimulated serotonin release suggest that the additional serotonin content found in thewv/wv striatum is in a releasable pool but that striatal serotonin release might be attenuated more inwv/wv than in +/+ mice.

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Authors and Affiliations

  1. Department of Psychiatry (Institute of Psychiatric Research), Indiana University School of Medicine, 791 Union Dr., 46202-4887, Indianapolis, Indiana

    B. Ghetti & J. R. Simon

  2. Department of Pathology and Laboratory Medicine (Neuropathology), Indiana University School of Medicine, 791 Union Dr., 46202-4887, Indianapolis, Indiana

    B. Ghetti

  3. Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, 791 Union Dr., 46202-4887, Indianapolis, Indiana

    J. R. Simon

  4. Program in Medical Neurobiology, Indiana University School of Medicine, 791 Union Dr., 46202-4887, Indianapolis, Indiana

    E. H. Stotz-Potter, B. Ghetti & J. R. Simon

Authors
  1. E. H. Stotz-Potter
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  2. B. Ghetti
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  3. J. R. Simon
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Stotz-Potter, E.H., Ghetti, B. & Simon, J.R. Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse. Neurochem Res 20, 821–826 (1995). https://doi.org/10.1007/BF00969694

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