Abstract
Juglone 5-hydroxy-1,4-napthoquinone exerts three activities on cortical synaptosomal preparations. It inhibits the release of acetylcholine and is an even more potent inhibitor of high-affinity choline transport into synaptosomes. In addition, as has already been shown by others using brain homogenates, juglone inhibits choline acetyltransferase.
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Cooper, J.R., Piros, K. The effect of juglone on cholinergic mechanisms in rat brain synaptosomes. Neurochem Res 2, 259–264 (1977). https://doi.org/10.1007/BF00969356
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DOI: https://doi.org/10.1007/BF00969356