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The role of proteolytic enzymes in demyelination in experimental allergic encephalomyelitis

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References

  1. Kies, M. W., andAlvord, E. C., Jr. (eds.). 1959. Allergic Encephalomyelitis, Charles C Thomas, Springfield, Illinois.

    Google Scholar 

  2. Research in Demyelinating Diseases. 1965. (Scheinberg, L. C., Kies, M. W., andAlvord, E. C., Jr., Conference Cochairmen.) Ann. N. Y. Acad. Sci. 122:1–570.

    Google Scholar 

  3. Waksman, B. H., andAdams, R. D. 1962. A histologic study of the early lesion in experimental allergic encephalomyelitis in the guinea pig and rabbit.Am. J. Pathol. 41:135–162.

    Google Scholar 

  4. Rauch, H. C., Einstein, E. R., andCsejtey, J. 1973. Enzymatic degradation of myelin basic protein in central nervous system lesions of monkeys with experimental allergic encephalomyelitis.Neurobiology 3:195–205.

    Google Scholar 

  5. Levine, S., andSowinski, R. 1973. Hyperacute allergic encephalomyelitis. A localized form produced by passive transfer and pertussis vaccine.Am. J. Pathol. 73:247–258.

    Google Scholar 

  6. Lampert, P. 1967. Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis.Acta Neuropathol. 9:99–126.

    Google Scholar 

  7. Morrison, L. R., andZamecnik, P. C. 1950. Experimental demyelination by means of enzymes, especially the alpha toxin ofClostridium welchii.Arch. Neurol. Psychiatry 63:367–381.

    Google Scholar 

  8. Maggio, B., Maccioni, H. J., andCumar, F. A. 1973. ArylsulfataseA (EC. 3.1.6.1) activity in rat central nervous system during EAE.J. Neurochem. 20:503–510.

    Google Scholar 

  9. Woelk, H., andKanig, K. 1974. Phospholipid metabolism in experimental allergic encephalomyelitis: Activity of brain phospholipaseA 1 towards specifically labelled glycero phospholipids.J. Neurochem. 23:739–743.

    Google Scholar 

  10. Woelk, H., Kanig, K., andPeiler-Ichikawa, K. 1974. Phospholipid metabolism in experimental allergic encephalomyelitis: Activity of mitochondrial phospholipaseA 2 of rat brain towards specifically labelled 1,2-diacyl-1-alk-1′-enyl-2 acyl- and 1-alkyl-2-acyl-SN-glycero-3 phosphorylcholine.J. Neurochem. 23:745–750.

    Google Scholar 

  11. Folch, J., andLees, M. 1951. Proteolipides, a new type of tissue lipoproteins. Their isolation from brain.J. Biol. Chem. 191:807–817.

    Google Scholar 

  12. Lees, M. B., Messinger, B. F., andBurnham, J. D. 1967. Tryptic hydrolysis of brain proteolipid.Biochem. Biophys. Res. Commun. 28:185–190.

    Google Scholar 

  13. Lees, M. B., andChan, D. S. 1975. Proteolytic digestion of bovine brain white matter proteolipid.J. Neurochem. 25:595–600.

    Google Scholar 

  14. Smith, M. E. Unpublished observations.

  15. Carnegie, P. R., andDunkley, P. R. 1975. Basic proteins of central and peripheral nervous system myelin. Pages 95–135,in Agranoff, B. W., andAprison, M. H. (eds.), Advances in Neurochemistry, Vol. I, Plenum Press, New York.

    Google Scholar 

  16. Eylar, E. H., Brostoff, S., Hashim, G., Caccam, J., andBurnett, P. 1971. BasicA 1 protein of the myelin membrane. The complete amino acid sequence.J. Biol. Chem. 246:5770–5784.

    Google Scholar 

  17. Carnegie, P. R. 1971. Amino acid sequence of the encephalitogenic basic protein from human myelin.Biochem. J. 123:57–67.

    Google Scholar 

  18. Einstein, E. R., Csejtey, J., andMarks, N. 1968. Degradation of encephalitogen by purified brain acid proteinase.FEBS Lett. 1:191–195.

    Google Scholar 

  19. Wolfgram, F., andKotorii, K. 1968. The composition of the myelin proteins of the central nervous system.J. Neurochem. 15:1281–1290.

    Google Scholar 

  20. Quarles, R. H., Everly, J. L., andBrady, R. O. 1972. Demonstration of a glycoprotein which is associated with a purified myelin fraction from rat brain.Biochem. Biophys. Res. Commun. 47:491–497.

    Google Scholar 

  21. Agrawal, H. C., Burton, R. M., Fishman, M. A., Mitchell, R. F., andPrensky, A. L. 1972. Partial characterization of a new myelin protein component.J. Neurochem. 19:2083–2089.

    Google Scholar 

  22. London, Y., andVossenberg, F. G. A. 1973. Specific interaction of central nervous system myelin basic protein with lipids. Specific regions of the protein sequence protected from the proteolytic action of trypsin.Biochem. Biophys. Acta 307:478–490.

    Google Scholar 

  23. Wood, J. G., Dawson, R. M. C., andHauser, H. 1974. Effect of proteolytic attack on the structure of CNS myelin membrane.J. Neurochem. 22:637–643.

    Google Scholar 

  24. Banik, N. L., andDavison, A. N. 1974. Lipid and basic protein interaction in myelin.Biochem. J. 143:39–45.

    Google Scholar 

  25. Marks, N., andLajtha, A. 1971. Protein and polypeptide breakdown. Pages 49–139,in Lajtha, A. (ed.), Handbook of Neurochemistry, Vol. 5, Pt. A, Plenum Press, New York.

    Google Scholar 

  26. Marks, N. 1968. Expopeptidases of the nervous system.Int. Rev. Neurobiol. 11:57–97, Academic Press, New York.

    Google Scholar 

  27. Kies, M. W., andSchwimmer, S. 1942. Observations on proteinase in brain.J. Biol. Chem. 145:685–691.

    Google Scholar 

  28. Hirsch, H. E., andParks, M. E. 1973. The quantitative histochemistry of acid proteinase in the nervous system: Localization in neurons.J. Neurochem. 21:453–458.

    Google Scholar 

  29. Ansell, G. B., andRichter, D. 1954. Evidence for a “neutral proteinase” in brain tissue.Biochim. Biophys. Acta 13:92–97.

    Google Scholar 

  30. Riekkinen, P. J., andRinne, U. K. 1968. A new neutral proteinase from rat brain.Brain Res. 9:126–135.

    Google Scholar 

  31. Bosmann, H. B. 1973. Protein catabolism. III. Proteolytic enzymes of guinea pig cerebral cortex and synaptosomal localization.Int. J. Pept. Protein Res. 5:135–147.

    Google Scholar 

  32. Bowen, D. M., andDavison, A. N. 1973. CathepsinA in human brain and spleen.Biochem. J. 131:417–419.

    Google Scholar 

  33. Marks, N., Datta, R. K., andLajtha, A. 1968. Partial resolution of brain arylamidases and aminopeptidases.J. Biol. Chem. 243:2882–2889.

    Google Scholar 

  34. Adams, C. W. M., Davison, A. N., andGregson, N. A. 1963. Enzyme inactivity of myelin: Histochemical and biochemical evidence.J. Neurochem. 10:383–395.

    Google Scholar 

  35. Beck, C. S., Hasinoff, C. W., andSmith, M. E. 1968.l-alanyl-β-naphthylamidase in rat spinal cord myelin.J. Neurochem. 15:1297–1301.

    Google Scholar 

  36. Reikkinen, P. J., andRumsby, M. G. 1972. Aminopeptidase and neutral proteinase activity associated with central nerve myelin preparation during purification.Brain Res. 41:512–517.

    Google Scholar 

  37. Kerekes, M. F., Feszt, T., andKovacs, A. 1965. Catheptic activity in the cerebral tissue of the rabbit during allergic encephalomyelitis.Experientia 21:42–43.

    Google Scholar 

  38. Benetato, G., Gabrielescu, E., andBoros, I. 1965. Histochemistry of cerebral proteases in experimental allergic encephalitis.Rev. Roum. Physiol. 2:379–384. (C. A. 64, 20401, 1966.)

    Google Scholar 

  39. Porcellati, G. 1972. Amino acid and protein metabolism in Wallerian degeneration. Pages 191–219,in Lajtha, A. (ed.), Handbook of Neurochemistry, Vol. 7, Plenum Press, New York.

    Google Scholar 

  40. Hallpike, J. F., andAdams, C. W. M. 1969. Proteolysis and myelin breakdown: A review of recent histochemical and biochemical studies.Histochem. J. 1:559–578.

    Google Scholar 

  41. Hallpike, J. F., Adams, C. W. M., andBayliss, O. B. 1970. Histochemistry of myelin. VIII. Proteolytic activity around multiple sclerosis plaques.Histochem. J. 2:199–208.

    Google Scholar 

  42. Roboz-Einstein, E., Csejtey, J., Davis, W. J., Lajtha, A., andMarks, N. 1969. Enzymatic degradation of the encephalitogenic protein. Add. adInt. Arch. Allergy 36:363–375.

    Google Scholar 

  43. Einstein, E. R., Dalal, K. B., andCsejtey, J. 1970. Increased protease activity and changes in basic proteins and lipids in multiple sclerosis plaques.J. Neurol. Sci. 11:109–121.

    Google Scholar 

  44. Einstein, E. R., Csejtey, J., Dalal, K. B., Adams, C. W. M., Bayliss, O. B., andHallpike, J. F. 1972. Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: Combined biochemical and histochemical observations.J. Neurochem. 19:653–662.

    Google Scholar 

  45. Smith, M. E., Sedgewick, L. M., andTagg, J. S. 1974. Proteolytic enzymes and experimental demyelination in the rat and monkey.J. Neurochem. 23:965–971.

    Google Scholar 

  46. Bowen, D. M., andDavison, A. N. 1974. Macrophages and cathepsinA activity in multiple sclerosis brain.J. Neurol. Sci. 21:227–231.

    Google Scholar 

  47. Govindarajan, K. R., Rauch, H. C., Clausen, J., andEinstein, E. R. 1974. Changes in cathepsinsB-1 andD, neutral proteinase, and 2′,3′-cyclic nucleotide-3′-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis.J. Neurol. Sci. 23:295–306.

    Google Scholar 

  48. Boehme, D. H., Fordice, M. W., andMarks, N. 1974. Proteolytic activity in brain and spinal cord in sensitive and resistant strains of rat and mouse subjected to experimental allergic encephalomyelitis.Brain Res. 75:153–162.

    Google Scholar 

  49. Buletza, G. F., Jr., andSmith, M. E. 1976. Enzymic hydrolysis of myelin basic protein and other proteins in central nervous system and lymphoid tissues from normal and demyelinating rats.Biochem. J. 156:627–633.

    Google Scholar 

  50. Barrett, A. J. 1975. Lysosomal and related proteinases. Pages 467–801,in Reich, E., Rifkin, D. B., andShaw, E. (eds.), Proteases and Biological Control, Cold Spring Harbor Conferences on Cell Proliferation, Vol. 2, Cold Spring Harbor.

  51. Hirsch, H. E., andParks, M. E. 1975. Acid proteinases and other acid hydrolases in experimental allergic encephalomyelitis: Pinpointing the source.J. Neurochem. 24:853–858.

    Google Scholar 

  52. Rauch, H. C., andEinstein, E. R. 1974. Specific brain proteins: A biochemical and immunological review. Pages 283–343,in Ehrenpreis, S., andKopin, I. J. (eds.), Review of Neuroscience, Vol. I, Raven Press, New York.

    Google Scholar 

  53. Smith, M. E. 1976. A lymph node neutral proteinase acting on myelin basic protein.J. Neurochem. 27:1077–1082.

    Google Scholar 

  54. Smith, M. E., andChow, S. H. 1976. Neutral proteinase in lymph nodes specific for basic protein.Trans. Am. Soc. Neurochem. 7:178.

    Google Scholar 

  55. Tokes, Z. A., andKiefer, H. 1976. Estimation of cell surface associated protease activity and its application to lymphocytes.J. Supramol. Struct. 4:507–513.

    Google Scholar 

  56. Allison, A. C., andFerluga, J. 1976. How lymphocytes kill tumor cells.N. Engl. J. Med. 295:165–167.

    Google Scholar 

  57. Benuck, M., Marks, N., andHashim, G. A. 1975. Metabolic instability of myelin proteins. Breakdown of basic protein induced by brain cathepsin D.Eur. J. Biochem. 52:615–621.

    Google Scholar 

  58. Marks, N., Grynbaum, A., andBenuck, M. 1976. On the sequential cleavage of myelin basic protein by catepsinsA andD.J. Neurochem. 27:765–768.

    Google Scholar 

  59. Grayzel, A. I., Hatcher, V. B., andLazarus, G. S. 1975. Protease activity of normal and PHA stimulated human lymphocytes.Cell Immunol. 18:210–219.

    Google Scholar 

  60. Yago, N., andBowers, W. E. 1975. Unique cathepsinD-type proteases in rat thoracic duct lymphocytes and in rat lymphoid tissues.J. Biol. Chem. 250:4749–4754.

    Google Scholar 

  61. Janoff, A. 1972. Neutrophil proteases in inflammation.Ann. Rev. Med. 23:177–190.

    Google Scholar 

  62. Riekkinen, P. J., Clausen, J., Frey, H. J., Fog, T., andRinne, U. K. 1970. Acid proteinase activity of white matter and plaques in multiple sclerosis.Acta Neurol. Scand. 46:349–353.

    Google Scholar 

  63. Cuzner, M. L., andDavison, A. N. 1973. Changes in cerebral lysosomal enzyme activity and lipids in multiple sclerosis.J. Neurol. Sci. 19:29–36.

    Google Scholar 

  64. Hirsch, H. E., Duquette, P., andParks, M. E. 1976. The quantitative histochemistry of multiple sclerosis plaques: Acid proteinase and other acid hydrolases.J. Neurochem. 26:505–512.

    Google Scholar 

  65. Govindarajan, K. R., Offner, H., Clausen, J., Fog, T., andHyllested, K. 1974. The lymphocytic cathepsinsB-1 andD activities in multiple sclerosis.J. Neurol. Sci. 23:81–87.

    Google Scholar 

  66. Cuzner, M. L., McDonald, W. I., Rudge, P., Smith, M., Borshell, N., andDavison, A. N. 1975. Leucocyte proteinase activity and acute multiple sclerosis.J. Neurol. Sci. 26:107–111.

    Google Scholar 

  67. Prineas, J. 1975. Pathology of the early lesion in multiple sclerosis.Hum. Pathol. 6:531–554.

    Google Scholar 

  68. Hirsch, H. E. 1976. The role of acid hydrolases in demyelination.Neurology 26(6), Pt. 2:39–41.

    Google Scholar 

  69. Levine, S., Simon, J., andWenk, E. J. 1966. Edema of the spinal cord in experimental allergic encephalomyelitis.Proc. Soc. Exp. Biol. Med. 123:539–541.

    Google Scholar 

  70. Marks, N., D'Monte, B., andLajtha, A. 1973. Inhibition of cerebral proteolytic enzymes.Tex. Rep. Biol. Med. 31:345–365.

    Google Scholar 

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  1. Department of Neurology, Veterans Administration Hospital, Palo Alto, California

    Marion Edmonds Smith

  2. Standord University School of Medicine, 94305, Stanford, California

    Marion Edmonds Smith

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Smith, M.E. The role of proteolytic enzymes in demyelination in experimental allergic encephalomyelitis. Neurochem Res 2, 233–246 (1977). https://doi.org/10.1007/BF00969354

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