Neurochemical Research

, Volume 11, Issue 12, pp 1677–1682 | Cite as

d-pipecolic acid inhibits ethanol tolerance in mice

  • Gyula Szabó
  • Gábor L. Kovács
  • Lajos Baláspiri
  • Gyula Telegdy
Original Articles

Abstract

The effects of graded doses ofd-pipecolic acid (0.005–5 μg/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice.d-pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeatedd-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed thatd-pipecolic acid is capable of counteracting the tolerance effect of ethanol.

Keywords

Single Dose Core Temperature Ethanol Tolerance Acid Administration Hypothermic Effect 

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Gyula Szabó
    • 1
  • Gábor L. Kovács
    • 1
  • Lajos Baláspiri
    • 2
  • Gyula Telegdy
    • 1
  1. 1.Department of PathophysiologyUniversity Medical SchoolSzegedHungary
  2. 2.Department of Medical ChemistryUniversity Medical SchoolSzegedHungary

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