Abstract
2′,3′-Cyclic nucleotide 3′-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of thecog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.
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Sugisaki, T., Beamer, W.G. & Noguchi, T. Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog). Neurochem Res 17, 1037–1040 (1992). https://doi.org/10.1007/BF00966833
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DOI: https://doi.org/10.1007/BF00966833