Abstract
Serum, liver and brain tryptophan concentrations and brain Na+K+-ATPase activity were studied in streptozotocin diabetic rats after an acute tryptophan load. Results show that tryptophan administration in the experimental diabetic group produces a generalized fall in tryptophan uptake in all the brain regions studied, though it does not increase serum and hepatic tryptophan concentrations. These parameters are normalized in insulin-treated diabetic rats. With regard to Na+K+-ATPase, diabetic animals showed a diminished and unchanged activity; whereas, the other two experimental groups showed a gradual decrease and a negative correlation with brain tryptophan uptake.
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Atienza, G., Andres, M.D., Rebolledo, E. et al. Brain tryptophan uptake and sodium-potassium ATPase activity in long-term streptozotocin diabetic rats. Neurochem Res 17, 289–292 (1992). https://doi.org/10.1007/BF00966672
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DOI: https://doi.org/10.1007/BF00966672