Skip to main content

Biopterin: IV. Regional and subcellular aspects ofl-erythro-7,8-dihydrobiopterin synthesis in brain

This is a preview of subscription content, access via your institution.


  1. Gál, E. M., andSherman, A. D. 1976. Biopterin II. Evidence for cerebral synthesis of 7,8-dihydrobiopterin in vivo and in vitro. Neurochem. Res. 1:627–639.

    Google Scholar 

  2. Gál, E. M., Nelson, J. M., andSherman, A. D. 1978. Biopterin III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin. Neurochem. Res. 3:69–88.

    PubMed  Google Scholar 

  3. Gál, E. M., andSherman, A. D. 1977. Rapid isolation and quantitation of biopterin, neopterin and their guanine ribotide precursor from biological samples. Prep. Biochem. 7:155–164.

    PubMed  Google Scholar 

  4. Gál, E. M., Hanson, G., andSherman, A. D. 1976. Biopterin I. Profile and quantitation in rat brain. Neurochem. Res. 1:511–523.

    Google Scholar 

  5. Lowry, O. H., Rosebrough, N. J., Farr, A. L., andRandall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.

    PubMed  Google Scholar 

  6. Schneider, W. G., andHogeboom, G. H. 1950. Intracellular distribution of enzymes. J. Biol. Chem. 183:123–132.

    Google Scholar 

  7. Schneider, R. M., andPetermann, M. L. 1950. Nuclei from normal and leukemic mouse spleen: I. The isolation of nuclei in neutral medium. Cancer Res. 10:751–754.

    PubMed  Google Scholar 

  8. Grey, E. G., andWhittaker, V. P. 1962. The isolation of nerve endings from brain: An electron-microscopic study of cell fragments derived by homogenization and centrifugation. J. Anat. 96:79–88.

    PubMed  Google Scholar 

  9. Cotman, C. W. 1974. Isolation of synaptosomal and synaptic plasma membrane fractions. Pages 445–452,in Fleischer, S., andPacken, L. (eds.), Methods in Enzymology, Vol. XXXI, Academic Press, New York.

    Google Scholar 

  10. Blomstrand, C., andHamberger, A. 1969. Protein turnover in cell enriched fractions from rabbit brain. J. Neurochem. 16:1401–1407.

    PubMed  Google Scholar 

  11. Buff, K., andDairman, W. A. 1975. Biosynthesis of biopterin in the intact rat and in mouse neuroblastoma cells. Pages 273–283,in Pfleiderer, W. (ed.), Chemistry and Biology of Pteridines, de Gruyter, New York.

    Google Scholar 

  12. Fukushima, K., Richter, W. E., Jr., andShiota, T. 1977. Partial purification of 6-(d-erythro-1′, 2′, 3′-trihydroxypropyl)-7,8-dihydropterin triphosphate synthetase from chicken liver. J. Biol. Chem. 252:5750–5755.

    PubMed  Google Scholar 

  13. Eto, I., Fukushima, K., andShiota, T. 1976. Enzymatic synthesis of biopterin fromd-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters. J. Biol Chem. 251:6505–6512.

    PubMed  Google Scholar 

  14. Costa-Tiozzo, R., andGál, E. M. 1977. Properties of crude ‘synaptosomes'’ (P2) versus those of purified synaptosomal preparations. Abstracts-VIth International Meeting of the International Society for Neurochemistry, p. 161.

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gál, E.M., Henn, F.A. & Sherman, A. Biopterin: IV. Regional and subcellular aspects ofl-erythro-7,8-dihydrobiopterin synthesis in brain. Neurochem Res 3, 493–499 (1978).

Download citation

  • Accepted:

  • Issue Date:

  • DOI:


  • Biopterin
  • Subcellular Aspect