Neurochemical Research

, Volume 15, Issue 5, pp 551–558 | Cite as

Learning-induced change in neural activity during acquisition and consolidation of a passive avoidance response in the rat

  • Emer Doyle
  • Patrick M. Nolan
  • Ciaran M. Regan
Original Articles

Abstract

Time-dependent alterations in neural activity have been established during the acquisition and consolidation of a stepdown passive avoidance paradigm. Change in neural activity was established by administering a glucose analogue, [3H]2-deoxyglucose, 50min prior to sacrifice and estimating perchloric acid soluble counts in nine hand dissected brain regions. Change in [3H]2-deoxyglucose uptake was closely paralleled in both trained and yoked animals for up to 40min following task acquisition however the striatum was the only area to exhibit a task-specific increase in [3H]2-deoxyglucose uptake at 20–30min after training. Longterm changes in neural activity were also apparent as the amygdala and brainstem showed increased [3H]2-deoxyglucose uptake at the 24h time point. No further paradigm-specific changes were apparent at 48 h. These findings are concluded to suggest that the striatum is involved in the early events of acquiring a passive avoidance response and the amygdala and brainstem during the later events.

Key Words

memory/learning passive avoidance deoxyglucose striatum amygdala brainstem 

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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Emer Doyle
    • 1
  • Patrick M. Nolan
    • 1
  • Ciaran M. Regan
    • 1
  1. 1.Department of PharmacologyUniversity CollegeDublin 4Ireland

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