Learning-induced change in neural activity during acquisition and consolidation of a passive avoidance response in the rat
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Time-dependent alterations in neural activity have been established during the acquisition and consolidation of a stepdown passive avoidance paradigm. Change in neural activity was established by administering a glucose analogue, [3H]2-deoxyglucose, 50min prior to sacrifice and estimating perchloric acid soluble counts in nine hand dissected brain regions. Change in [3H]2-deoxyglucose uptake was closely paralleled in both trained and yoked animals for up to 40min following task acquisition however the striatum was the only area to exhibit a task-specific increase in [3H]2-deoxyglucose uptake at 20–30min after training. Longterm changes in neural activity were also apparent as the amygdala and brainstem showed increased [3H]2-deoxyglucose uptake at the 24h time point. No further paradigm-specific changes were apparent at 48 h. These findings are concluded to suggest that the striatum is involved in the early events of acquiring a passive avoidance response and the amygdala and brainstem during the later events.
Key Wordsmemory/learning passive avoidance deoxyglucose striatum amygdala brainstem
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- 2.Berman, R. F., Kesner, R. P., Partlow, L. M. 1978. Passive avoidance impairment in rats following cycloheximide injection into the amygdala. Brain Res 158:171–178.Google Scholar
- 7.Delanoy, R. L., Dunn, A. J. 1978. Mouse brain deoxyglucose uptake after footshock, ACTH analogues, α-MSH, corticosterone or lysine vasopressin. Pharmacol Biochem and Behavior 9:21–26.Google Scholar
- 11.Greenough, W. T., Chang, F. L. F. 1985. Synaptic structural correlates of information storage in mammalian nervous systems. In Cotman C. W. (ed) “Synaptic Plasticity”. New York: Guilford Press pp335–372.Google Scholar
- 17.Kossut, M., Rose, S. P. R. 1984. Differential 2-deoxyglucose uptake into the chick brain structures during passive avoidance training. Neurosci 12:971–977.Google Scholar
- 22.Morris, R. G. M., Hagan, J. J., Nadel, L., Jenson, J., Baudry, M., Lynch, G. S. 1987. Spatial learning in the rat: Impairment induced by the thiol proteinase inhibitor, leupeptin, and an analysis of 3H glutamate receptor binding in relation to learning. Behav Neural Biol 47:333–345.PubMedGoogle Scholar
- 23.Olton, D. S. 1983. Memory functions and the hippocampus. In W. Seifert (Ed) ‘Neurobiology of the hippocampus’ New York: Academic Press.Google Scholar
- 24.Plum, F., Gjedde, A., Samson, F. E. 1976. Neuroanatomical functional mapping by the radioactive 2-deoxy-D glucose method. Neurosci Res Prog Bull 14:457–518.Google Scholar
- 27.Reivich, M., Sokoloff, L. 1976. Application of the 2-deoxy-D-glucose method to the coupling of cerebral metabolism and blood flow. Neurosci Res Prog Bull 14:474–475.Google Scholar
- 34.Sokoloff, L., Reivich, M., Kennedy, C., Des Rosier, M. H., Palak, C. S., Pettigrew, K. D., Sakurada, O., Shinohara, M. 1977. The 14C-deoxyglucose method of measurement of local cerebral glucose utilisation: theory, procedures and normal values in the conscious and anaesthetised albino rat. J Neurochem 28:897–916.PubMedGoogle Scholar
- 35.Squire, L. R. 1987. Memory and brain. New York and Oxford: Oxford University Press.Google Scholar