Neurochemical Research

, Volume 1, Issue 2, pp 191–200 | Cite as

Stimulation of thiamine triphosphate metabolism in nerve by cyclic guanosine 3′,5′-monophosphate

  • Sven G. Eliasson
  • JoAnne D. Scarpellini
Article

Abstract

This paper reports that addition of cGMP results in an increase of the amount of32Pi incorporated into thiamine triphosphate in nerve roots and sympathetic trunks. The effect is present both at rest and during electrical stimulation. Other nucleotides were less effective. Theophylline increased the incorporation, possibly because of phosphodiesterase inhibition. A blocking effect of atropine was noted in sympathetic trunk preparations that contain ganglion cells.

Keywords

Nucleotide Electrical Stimulation Theophylline Triphosphate Atropine 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Sven G. Eliasson
    • 1
  • JoAnne D. Scarpellini
    • 1
  1. 1.Department of Neurology and Neurological Surgery (Neurology)Washington University School of MedicineSt. Louis

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