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Anoxic block of GABAergic IPSPs

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Abstract

In rat hippocampal slices GABAergic IPSPs are very rapidly suppressed by anoxia (in<2 min). Both early (GABAA) and late (GABAB) components are affected. After reoxygenation, the IPSPs recover, but only slowly and not always completely. Iontophoretic applications of GABA or baclofen indicated no major depression of responses during anoxia. It is therefore unlikely that the anoxic suppression of IPSPs is caused by desensitizations of GABA receptors. A more probable explanation is a failure of GABAergic neurons to release GABA from inhibitory nerve terminals.

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Author notes

  1. Y. Z. Xu

    Present address: Department of Biology, University of Science and Technology, of China, Hefei, China

  2. L. Zhang

    Present address: Playfair Neuroscience Unit, Toronto Western Hospital, Room 12-314, 399 Bathurst Street, M5T 2S8, Toronto, Ontariol

Authors and Affiliations

  1. Anaesthesia Research Department, McGill University, Montréal, Québec, Canada

    K. Krnjević

  2. McIntyre Centre for Medical Sciences, Room 1208, 3655 Drummond Street, H3G 1Y6, Montréal, Qué, Canada

    K. Krnjević

Authors
  1. K. Krnjević
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  2. Y. Z. Xu
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  3. L. Zhang
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Special issue dedicated to Dr. Eugene Roberts.

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Krnjević, K., Xu, Y.Z. & Zhang, L. Anoxic block of GABAergic IPSPs. Neurochem Res 16, 279–284 (1991). https://doi.org/10.1007/BF00966091

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