Neurochemical Research

, Volume 16, Issue 3, pp 251–262

Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy

  • Jeffrey G. Tasker
  • F. Edward Dudek
Original Articles

DOI: 10.1007/BF00966088

Cite this article as:
Tasker, J.G. & Dudek, F.E. Neurochem Res (1991) 16: 251. doi:10.1007/BF00966088


Epileptogenic conditions come about from a disequilibrium between excitatory and inhibitory mechanisms, creating a state of neuronal hypersynchrony. From experimental studies in animal models of epilepsy it appears that several mechanisms, alone or in combination, could be responsible for this imbalance. An alteration of GABA-mediated inhibition has long been considered to be one of the most likely candidates. We review recent data on the synaptic physiology of GABA-mediated inhibition, with emphasis on GABAA and GABAB receptors and their conductances. We describe the integrative role of GABAergic local-circuit neurons in the normal control of recurrent excitation. We then discuss possible alterations in GABAA-mediated inhibition in two chronic animal models of epilepsy, the kindled rat and the kainate-treated rat. Finally, we review studies on GABA inhibition in human epileptic cortex resected for the treatment of intractable epilepsy.

Key Words

Seizure burst inhibition hippocampus neocortex slice preparation 

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Jeffrey G. Tasker
    • 1
  • F. Edward Dudek
    • 1
  1. 1.Mental Retardation Research Center and Brain Research InstituteUCLA School of MedicineLos Angeles

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